How do the activities of daily living decline in people living with rarer dementias? A systematic review
How do the activities of daily living decline in people living with rarer dementias? A systematic review
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罕见痴呆症患者的日常生活活动如何下降？
DOI：
10.1101/2022.09.22.22280192
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Taylor B
中科院分区：
文献类型：
--
作者：
Taylor B
目的通过对文献的系统回顾，研究日常生活活动能力 (ADL) 在罕见痴呆症（患病率低于 10%）的进展过程中如何下降。方法通过搜索 Medline、Embase、Emcare、PsycINFO 和 Cinahl 找到相关研究。使用在国际前瞻性系统评价登记册（注册号：CRD42021283302）注册的预先制定的方案，在数据库中搜索与（罕见痴呆）AND（日常生活活动）AND（纵向或横断面研究）相关的术语。结果共筛选了 579 篇文章的相关内容，其中 20 篇全文出版物纳入分析。十九项研究涉及额颞叶痴呆/原发性进行性失语症谱系中较罕见的痴呆，其中一项研究涉及后皮质萎缩。对衰退的长期描述仅限于对患者进行超过五年的七项研究。还强调了下降率、症状出现顺序和症状持续时间。结论 ADL 进展的描述不够长期，涵盖症状出现后平均 3.5 年，并且缺乏表型特异性。文献不成比例地研究了额颞叶痴呆谱系的痴呆。为了促进更好的护理，需要更多的纵向数据、定量分析和开发更罕见的痴呆症特异性 ADL 量表。鉴于罕见痴呆症的患病率较低，大数据分析可能永远不适用，因此应该追求个性化医疗方法，包括数字生物标记物的创新可能性，例如可穿戴技术。
ObjectiveTo study how activities of daily living (ADLs) decline over the progressive course of rarer dementias (prevalence below 10%), in a systematic review of the literature.Methods Relevant studies were identified by searching Medline, Embase, Emcare, PsycINFO and Cinahl. The databases were searched for terms relating to (rarer dementias) AND (activities of daily living) AND (longitudinal OR cross-sectional studies), using a pre-established protocol registered with the international prospective register of systematic reviews (registration: CRD42021283302).ResultsA total of 579 articles were screened for relevant content, of which 20 full-text publications were included in the analysis. Nineteen studies were about rarer dementias on the frontotemporal dementia/primary progressive aphasia spectrum, and one was about posterior cortical atrophy. Long term description of decline was limited to just seven studies following patients for longer than five years. The rate of decline, sequence of symptom onset, and symptom duration were also highlighted.ConclusionDescriptions of ADL progression were inadequately long term, covering an average of 3.5 years from symptom onset, and lacked phenotypic specificity. The literature disproportionately studied dementias on the frontotemporal dementia spectrum. To facilitate better care, more longitudinal data, quantitative analyses, and development of rarer dementia-specific ADL scales is needed. Given the low prevalence of rarer dementias, big data analyses may never be applicable and so personalised medicine approaches should be pursued, including innovative possibilities in digital biomarkers such as from wearable technology.