Physiological functions of vitamin D: what we have learned from global and conditional VDR knockout mouse studies
Physiological functions of vitamin D: what we have learned from global and conditional VDR knockout mouse studies
复制标题
DOI：
10.1016/j.coph.2015.04.001
复制
发表时间：
2015-06-01
影响因子：
4
通讯作者：
Carmeliet, Geert
中科院分区：
文献类型：
--
作者：
Suda, Tatsuo;Masuyama, Ritsuko;Carmeliet, Geert
维生素D的生理作用取决于钙的供应和钙平衡。当钙平衡正常时，维生素D的主要作用靶点是肠道。维生素D主要刺激肠道主动钙转运机制。在钙负平衡期间，维生素D对骨骼的作用变得占主导地位。因此，在这些情况下，维生素D在维持血钙正常方面的作用似乎优先于骨骼完整性。
The physiological role of vitamin D depends on calcium supply and calcium balance. When the calcium balance is normal, the major target of vitamin D is intestine. Vitamin D stimulates mainly active intestinal calcium transport mechanism. During a negative calcium balance, bone effects of vitamin D become dominant. Thus, the role of vitamin D in maintaining normocalcemia appears to have priority over skeletal integrity in these situations.