The relation between open-field and emergence tests in a hyperactive mouse model
The relation between open-field and emergence tests in a hyperactive mouse model
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DOI：
10.1016/j.neuropharm.2009.07.010
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发表时间：
2009-12-01
影响因子：
4.7
通讯作者：
Strazielle, C.
中科院分区：
文献类型：
--
作者：
Lalonde, R.;Strazielle, C.
在患有特发性高血压的小鼠中检查旷场试验和羽化试验之间的关系。自发性高血压小鼠（SHM）跨越更多的节段和饲养更经常在开放领域比血压正常的控制在这两个年龄水平。相比之下，理毛事件仅在老年SHM队列中减少。虽然年轻的SHM出现更快地从一个玩具对象只有部分，完全出现更快，只有在老年SHM队列。在整个系列中，旷场段与2-和4-爪出现延迟呈负相关。也有一个rears和2爪出现之间的负相关，但梳理事件和这两种类型的出现之间的正相关。鉴于其与旷场活动的相关性，出现测试可能在筛选潜在的ADHD治疗方法中具有价值。(C)2009爱思唯尔有限公司版权所有。
The relation between open-field and emergence tests was examined in mice with idiopathic hypertension. Spontaneous hypertensive mice (SHM) crossed more segments and reared more often in the open-field than normotensive controls at both age levels. in contrast, grooming episodes decreased only in the older SHM cohort. While young SHM emerged more quickly from a toy object only partially, complete emergence was faster only in the older SHM cohort. in the entire series, open-field segments were inversely correlated with 2- and 4-paw emergence latencies. There was also an inverse correlation between rears and 2-paw emergence but a positive correlation between grooming episodes and both types of emergence. In view of its association with open-field activity, the emergence test may have value in screening potential ADHD therapies. (C) 2009 Elsevier Ltd. All rights reserved.