C-Reactive Protein: The Most Familiar Stranger
C-Reactive Protein: The Most Familiar Stranger
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C反应蛋白：最熟悉的陌生人
DOI：
10.4049/jimmunol.2200831
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发表时间：
2023-03-15
影响因子：
4.4
通讯作者：
Wu, Yi
中科院分区：
文献类型：
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作者：
Ji, Shang-Rong;Zhang, Shu-Hao;Wu, Yi
C - 反应蛋白（CRP）是一种高度保守的五聚蛋白，具有模式识别受体样活性。然而，尽管它被广泛用作炎症的临床标志物，但CRP在体内的功能及其在健康和疾病中的作用在很大程度上仍未确定。这在一定程度上是由于CRP在小鼠和大鼠中的表达模式差异极大，这引发了人们对CRP的功能在不同物种间是否必要且保守，以及应如何操作这些模式动物以研究人CRP在体内的作用的担忧。在这篇综述中，我们讨论了近期强调CRP在不同物种间必要且保守功能的研究进展，并提出可以使用设计合理的动物模型来了解人CRP在体内依赖于来源、构象和定位的作用。改进的模型设计将有助于确定CRP的病理生理作用，并促进新型CRP靶向策略的开发。
C-reactive protein (CRP) is a highly conserved pentraxin with pattern recognition receptor -like activities. However, despite being used widely as a clinical marker of inflamma-tion, the in vivo functions of CRP and its roles in health and disease remain largely unestablished. This is, to certain extent, due to the drastically different expression patterns of CRP in mice and rats, raising concerns about whether the functions of CRP are essential and conserved across species and how these model animals should be manipulated to examine the in vivo actions of human CRP. In this review, we discuss recent advances highlighting the essential and conserved functions of CRP across species, and propose that appropriately designed animal models can be used to understand the origin-, conformation-, and localization -dependent actions of human CRP in vivo. The improved model design will contribute to establishing the pathophysi-ological roles of CRP and facilitate the development of novel CRP-targeting strategies.