Glutamatergic dysfunction in OCD
Glutamatergic dysfunction in OCD
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DOI：
10.1038/sj.npp.1300733
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发表时间：
2005-09-01
影响因子：
7.6
通讯作者：
Khanna, S
中科院分区：
文献类型：
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作者：
Chakrabarty, K;Bhattacharyya, S;Khanna, S
尽管最近的报道暗示强迫症中的多巴胺能功能障碍，但多巴胺能功能障碍在强迫症病理生理学中的作用几乎没有被探索。我们决定研究成年强迫症先证者与精神病学正常对照者的脑脊液谷氨酸水平。总共有21名同意使用SCID-IV-CV诊断的精神药物初治的成人OCD患者和18名同意的精神病学正常对照，患者年龄在10岁以内，没有任何头部损伤或神经系统疾病史，被纳入研究。采用无菌采集和储存的患者和对照受试者CSF样本进行谷氨酸估算，这是通过修改隆德（1986）描述的程序进行的。协方差分析发现，强迫症患者（47.12+/-4.25）的CSF谷氨酸（μ mol/l）水平显著高于对照组（41.36+/-3.63）[F（1，31）= 6.846，p = 0.014]。性别、年龄、病程、Y-BOCS评分或CGI-S评分对CSF谷氨酸水平无影响。我们的研究提供了初步证据，暗示在强迫症的病理生理学，这需要进一步探讨来自其他中心的研究，涉及来自不同年龄组的较大样本集。
The role of glutamatergic dysfunction in the pathophysiology of OCD has hardly been explored despite recent reports implicating glutamatergic dysfunction in OCD. We decided to investigate CSF glutamate levels in adult OCD probands compared to psychiatrically normal controls. In total, 21 consenting psychotropic drug-naive adult OCD patients, diagnosed using SCID-IV-CV, and 18 consenting psychiatrically normal controls with age within 10 years of age of the patients, who did not have any history of head injury or neurological illness, were included into the study. Aseptically collected and stored CSF samples obtained from the patients and control subjects were used for glutamate estimation, which was carried out by a modification of the procedure described by Lund (1986). CSF glutamate (mu mol/l) level was found to be significantly higher [F(1,31) = 6.846, p = 0.014] in OCD patients (47.12+/-4.25) compared to control subjects (41.36+/-3.63) on analysis of covariance. There was no effect of gender, age, duration of illness, Y-BOCS score, or CGI-S score on CSF glutamate levels. Our study provides preliminary evidence implicating glutamatergic excess in the pathophysiology of OCD, which needs to be further explored by studies from other centers involving larger sample sets from different age groups.