Localization and Release of Glutamic Acid in Relation to the Hippocampal Mossy Fibre Pathway
Localization and Release of Glutamic Acid in Relation to the Hippocampal Mossy Fibre Pathway
复制标题
谷氨酸的定位和释放与海马苔藓纤维通路的关系
作者：
I. Crawford;J. Connor
大量的临床和实验证据表明，海马参与颞叶癫痫1，2。与该疾病相关的一些兴奋症状可能与海马体对机械、电和化学刺激产生癫痫发作的明显倾向有关3。颞叶的局灶性放电可以通过直接传入传入扩散到附近的内嗅皮层4。来自内嗅神经元的兴奋性投射通过与齿状回的颗粒细胞进行突触接触而形成感觉新皮层和海马之间的链条中的最后一个环节。从颗粒细胞产生的轴突突触，反过来，在CA 3 -4海马锥体细胞的顶端树突。这些轴突构成苔藓纤维通路5。
ABUNDANT clinical and experimental evidence indicates that the hippocampus is involved in temporal lobe epilepsy1,2. Some of the symptoms of excitation associated with the disease may be related to the marked tendency of the hippocampus to produce seizures in response to mechanical, electrical and chemical stimuli3. Focal discharges in the temporal lobe could spread through direct afferents to the nearby entorhinal cortex4. Excitatory projections from entorhinal neurones form the final link in the chain between the sensory neocortex and the hippocampus by making synaptic contact with granule cells of the dentate gyrus. Axons arising from the granule cells synapse, in turn, on the apical dendrites of CA3–4 hippocampal pyramidal cells. These axons comprise the mossy fibre pathway5.