Evaluation of medetomidine-ketamine and dexmedetomidine-ketamine in Chinese water deer (Hydropotes inermis)
Evaluation of medetomidine-ketamine and dexmedetomidine-ketamine in Chinese water deer (Hydropotes inermis)
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DOI：
10.1111/j.1467-2995.2010.00591.x
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发表时间：
2011-03-01
影响因子：
1.7
通讯作者：
Gasthuys, Frank
中科院分区：
文献类型：
--
作者：
Bouts, Tim;Taylor, Polly;Gasthuys, Frank
目的观察美托咪定或右美托咪定与氯胺酮联合应用对自由放养中国水鹿（CWD）的生理及镇静制动作用。方法用0.08 +/- 0.004 mg/kg（-1）美托咪定和3.2 +/- 0.2 mg/kg（-1）氯胺酮（MK）或0.04 +/-0.2mg/kg（-1）氯胺酮（MK）肌肉注射动物。0.01 mg kg（-1）右美托咪定和2.9 +/- 0.1 mg kg（-1）氯胺酮（DMK）如果动物在制动60分钟后仍侧卧，则静脉内给予阿替美唑（MK：0.4 +/- 0.02 mg kg（-1），DMK：0.2 +/- 0.03 mg kg（-1））。每隔5分钟记录心率（HR）、呼吸频率（f（R））和体温。在初次注射后15和45分钟采集动脉血。使用学生t检验或ANOVA进行统计分析。结果两组动物均能迅速平卧。大多数人都有不自主的耳朵抽搐，但对外界刺激没有反应。平均HR无统计学差异（MK：75 +/- 14次/分钟（-1）; DMK：85 +/- 21次/分钟（-1）），f（R）（MK：51 +/- 35次呼吸分钟（-1）; DMK：36 +/- 9次呼吸分钟（-1）），体温（MK：38.1 +/- 0.7 ℃; DMK：38.4 +/- 0.5 ℃），血气值（MK：PaO（2）63 +/- 6 mmHg，PaCO（2）49.6 +/- 2.6 mmHg，HCO（3）（-）30.8 +/- 4.5 mmol L（-1）; DMK：PaO（2）77 +/- 35 mmHg，PaCO（2）45.9 +/- 11.5 mmHg，HCO（3）（-）31.0 +/- 4.5 mmol L（-1））和生化值，但两组体温均降低。所有动物在60分钟后需要拮抗制动。恢复迅速，平安无事。有没有不良反应后recovery.Conclusion和临床意义两种麻醉协议提供了令人满意的固定。两种方案都没有明显的偏好，似乎都适合慢性消耗病。
Objective To investigate physiological and sedative/ immobilization effects of medetomidine or dexmedetomidine combined with ketamine in free-ranging Chinese water deer (CWD).Study design Prospective clinical trial.Animals 10 free-ranging adult Chinese water deer (11.0 +/- 2.6 kg).Methods Animals were darted intramuscularly with 0.08 +/- 0.004 mg kg(-1) medetomidine and 3.2 +/- 0.2 mg kg(-1) ketamine (MK) or 0.04 +/- 0.01 mg kg(-1) dexmedetomidine and 2.9 +/- 0.1 mg kg(-1) ketamine (DMK) If the animal was still laterally recumbent after 60 minutes of immobilization, atipamezole was administered intravenously (MK: 0.4 +/- 0.02 mg kg(-1), DMK: 0.2 +/- 0.03 mg kg(-1)). Heart rate (HR) respiratory rate (f(R)) and temperature were recorded at 5-minute intervals. Arterial blood was taken 15 and 45 minutes after initial injection. Statistical analysis was performed using Student's t-test or ANOVA. p < 0.05 was considered significant.Results Animals became recumbent rapidly in both groups. Most had involuntary ear twitches, but there was no response to external stimuli. There were no statistical differences in mean HR (MK: 75 +/- 14 beats minute(-1); DMK: 85 +/- 21 beats minute(-1)), f(R) (MK: 51 +/- 35 breaths minute(-1); DMK; 36 +/- 9 breaths minute(-1)), temperature (MK: 38.1 +/- 0.7 degrees C; DMK: 38.4 +/- 0.5 degrees C), blood gas values (MK: PaO(2) 63 +/- 6 mmHg, PaCO(2) 49.6 +/- 2.6 mmHg, HCO(3)(-) 30.8 +/- 4.5 mmol L(-1); DMK: PaO(2) 77 +/- 35 mmHg, PaCO(2) 45.9 +/- 11.5 mmHg, HCO(3)(-) 31.0 +/- 4.5 mmol L(-1)) and biochemical values between groups but temperature decreased in both groups. All animals needed antagonism of immobilization after 60 minutes. Recovery was quick and uneventful. There were no adverse effects after recovery.Conclusion and clinical relevance Both anaesthetic protocols provided satisfactory immobilisation. There was no clear preference for either protocol and both appear suitable for CWD.