High serum haptoglobin level is associated with tumor progression and predicts poor prognosis in non-small cell lung cancer.
High serum haptoglobin level is associated with tumor progression and predicts poor prognosis in non-small cell lung cancer.
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DOI：
10.18632/oncotarget.9676
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发表时间：
2016-07-05
期刊：
影响因子：
--
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Lu J;Wang Y;Yan M;Feng P;Yuan L;Cai Y;Xia X;Liu M;Luo J;Li L
近几十年来，非小细胞肺癌（NSCLC）的总生存时间并没有显着改善。一个重要原因是缺乏有价值的生物标志物。据报道，触珠蛋白具有抗炎、抗氧化、自身免疫和肿瘤血管生成等活性。然而，其作为肿瘤生物标志物的潜在作用尚未得到充分认识。我们使用免疫比浊法测量 205 名 NSCLC 患者和 210 名正常健康对照者的血清触珠蛋白水平。我们发现，与正常健康对照相比，NSCLC 患者血清触珠蛋白水平显着升高（分别为 1.985±1.039 mg/mL 与 0.922 ± 0.495 mg/mL，P < 0.0001）。较高的血清触珠蛋白水平与晚期TNM分期、淋巴结转移和远处转移相关。血清触珠蛋白的受试者工作特征曲线下面积 (ROC) 为 0.809 (95% CI: 0.767–0.852)，特异性为 0.881，敏感性为 0.639。用于区分 NSCLC 和正常健康对照的触珠蛋白的最佳截止值为 1.495 mg/mL。 Kaplan-Meier时序分析显示，血清触珠蛋白水平较高组的总生存期低于触珠蛋白水平较低组（中位生存期分别为12.0周、26.0周，P < 0.01）。进一步单因素和多因素Cox回归分析显示血清触珠蛋白是NSCLC患者预后的独立危险因素（分别P<0.01、P=0.01）。总之，我们的研究表明血清触珠蛋白可能作为非小细胞肺癌进展和预后评估中有用的临床血清学生物标志物。
The overall survival time of non-small cell lung cancer (NSCLC) has not improved dramatically in recent decades. An important reason is the lacking of valuable biomarkers. Haptoglobin was reported to have activities of anti-inflammatory, anti-oxidant, autoimmune and tumor angiogenesis. However its potential role as a tumor biomarker was not well recognized. We used an immunoturbidimetry method to measure serum haptoglobin levels in 205 NSCLC patients, and 210 normal healthy controls. We found that serum haptoglobin levels were significantly elevated in NSCLC patients compared with normal healthy controls (1.985±1.039 mg/mLvs. 0.922 ± 0.495 mg/mL, respectively, P < 0.0001). Higher serum haptoglobin levels were associated with advanced TNM stage, lymph node metastasis, and distant metastasis. Area under receiver operating characteristic curve (ROC) for serum haptoglobin was 0.809 (95% CI: 0.767–0.852) at a specificity of 0.881 and sensitivity of 0.639. The optimal cut-off value of haptoglobin was 1.495 mg/mL for discriminating NSCLC from normal healthy controls. Kaplan-Meier log rank analysis revealed that the higher serum haptoglobin levels group had a poorer overall survival compared with lower haptoglobin group (the median survival was 12.0 weeks, 26.0 weeks, respectively, P < 0.01). Further univariate and multivariate Cox regression analysis showed that serum haptoglobin was an independent risk factor of prognosis of NSCLC patients (P < 0.01, P = 0.01, respectively). In conclusion, our study suggests that serum haptoglobin may act as useful clinical serological biomarkers in progression and prognostic evaluation in NSCLC.
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