Colonoscopy results of a French regional FOBT-based colorectal cancer screening program with high compliance
Colonoscopy results of a French regional FOBT-based colorectal cancer screening program with high compliance
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DOI：
10.1055/s-2007-995430
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发表时间：
2008-05-01
期刊：
影响因子：
9.3
通讯作者：
Bretagne, J. -F.
中科院分区：
文献类型：
--
作者：
Manfredi, S.;Piette, C.;Bretagne, J. -F.
研究背景和研究目的：法国在试点地区开展了结肠直肠癌的大规模筛查，在粪便潜血试验（FOBT）的基础上，对阳性病例进行结肠镜检查。我们报告的结肠镜检查结果在第一个领域之一，以筛选（Ille等Vilaine）。患者和方法：总区域人口908449，187342的213635潜在的筛选候选人谁是年龄在50-74岁被邀请FOBT。在51.3%的依从性个体中，2.6%为阳性，其中90.7%同意接受结肠镜检查（n=2246）。记录结肠镜检查程序的详细信息、结果和并发症。根据最晚期病变对受试者进行分类。结果：结肠镜检查完成率为96.3%。仅发生23例不良事件（1.02%）。结直肠癌237例（10.6%，其中78.4%为1-11期）。总体腺瘤和进展期腺瘤的发生率分别为33.1%和21.6%。癌症和晚期腺瘤的风险显着增加，在男性和老年people.Conclusion：在这项以人群为基础的研究中，大规模筛查FOBT结肠镜检查的结果是非常令人鼓舞的依从性，早期发现，并发症。将这一计划推广到整个法国是有道理的。
Background and study aims: Mass screening for colorectal cancer in France was initiated in pilot regions on the basis of the fecal occult blood test (FOBT) followed by colonoscopy in positive cases. We report the colonoscopy results in one of the first areas to be screened (Ille et Vilaine).Patients and methods: Of the total regional population of 908449, 187342 of the 213635 potential screening candidates who were aged 50-74 years were invited for FOBT. Of the 51.3% compliant individuals, 2.6% were positive, and of these 90.7% agreed to undergo colonoscopy (n=2246). The colonoscopy procedure details, findings, and complications were recorded. Subjects were classified according to the most advanced lesion. Positive predictive values of FOBT were calculated according to sex and age.Results: Colonoscopy was complete in 96.3% of cases. Only 23 adverse events were encountered (1.02%). Colorectal cancer was diagnosed in 237 cases (10.6%, 78.4% of which were clinical stages 1-11). The rates of overall adenomas and advanced adenomas were 33.1% and 21.6%, respectively. The risk of cancer and advanced adenoma increased significantly in men and in older people.Conclusion: The results of mass screening with FOBT followed by colonoscopy in this population-based study are very encouraging in terms of compliance, early findings, and complications. Extension of this program to the whole of France is justified.