Wheat microbiome bacteria can reduce virulence of a plant pathogenic fungus by altering histone acetylation.
Wheat microbiome bacteria can reduce virulence of a plant pathogenic fungus by altering histone acetylation.
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小麦微生物组细菌可以通过改变组蛋白乙酰化来降低植物病原真菌的毒力
DOI：
10.1038/s41467-018-05683-7
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发表时间：
2018-08-24
影响因子：
16.6
通讯作者：
Ma Z
中科院分区：
文献类型：
--
作者：
Chen Y;Wang J;Yang N;Wen Z;Sun X;Chai Y;Ma Z
细菌和真菌之间的相互作用在环境、医学和农业方面具有重要意义，但其分子机制在很大程度上尚不清楚。在这里，我们研究了来自小麦头微生物组的细菌Pseudomonas piscium和植物病原真菌Fusarium graminearum之间的相互作用。我们发现，由细菌分泌的化合物（吩嗪-1-甲酰胺）直接影响真菌蛋白FgGcn 5的活性，FgGcn 5是佐贺复合物的组蛋白乙酰转移酶。这导致禾谷镰刀菌中H2 BK 11、H3 K14、H3 K18和H3 K27处的组蛋白乙酰化的失调，以及真菌生长、毒力和真菌毒素生物合成的抑制。因此，拮抗细菌可以通过操纵真菌组蛋白修饰来抑制植物病原真菌的生长和毒力。
Interactions between bacteria and fungi have great environmental, medical, and agricultural importance, but the molecular mechanisms are largely unknown. Here, we study the interactions between the bacteriumPseudomonas piscium, from the wheat head microbiome, and the plant pathogenic fungusFusarium graminearum. We show that a compound secreted by the bacteria (phenazine-1-carboxamide) directly affects the activity of fungal protein FgGcn5, a histone acetyltransferase of the SAGA complex. This leads to deregulation of histone acetylation at H2BK11, H3K14, H3K18, and H3K27 inF.graminearum, as well as suppression of fungal growth, virulence, and mycotoxin biosynthesis. Therefore, an antagonistic bacterium can inhibit growth and virulence of a plant pathogenic fungus by manipulating fungal histone modification.