Gonadal hormones influence the immune response to PLP 139-151 and the clinical course of relapsing experimental autoimmmune encephalomyelitis
Gonadal hormones influence the immune response to PLP 139-151 and the clinical course of relapsing experimental autoimmmune encephalomyelitis
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DOI：
10.1016/s0165-5728(97)00214-2
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发表时间：
1998-04-15
影响因子：
3.3
通讯作者：
Offner, H
中科院分区：
文献类型：
--
作者：
Bebo, BF;Zelinka-Vincent, E;Offner, H
女性多发性硬化症的发病率增加(2：1)。使用复发性实验性自身免疫性脑脊髓炎(R-EAE)的小鼠模型可以有效地研究这种性别二型性。我们先前证明，用蛋白脂蛋白(PLP)多肽139-151免疫的雄性SJL小鼠出现了最初的瘫痪发作，但没有复发。在本研究中，临床上的EAE复发是由切除引起的。去势小鼠的复发伴随着活化的CD4(+)，Th1细胞涌入中枢神经系统，而假手术小鼠则没有。我们的数据表明，雄激素对PLP139-151的免疫反应和R-EAE的临床病程具有重要的调节作用。(C)1998年爱思唯尔科学公司。
Females have an increased incidence of multiple sclerosis (2:1). This gender dimorphism can be studied effectively using a murine model of relapsing experimental autoimmune encephalomyelitis (R-EAE). We demonstrated previously that male SJL mice immunized with proteolipid protein (PLP) peptide 139-151 developed an initial episode of paralysis, but failed to relapse. In the present study, clinical EAE relapses were induced by orchidectomy. Relapses in castrated mice were accompanied by an influx of activated CD4(+), Th1 cells into the CNS which were absent in sham mice. Our data suggests an important regulatory role for androgens on the immune response to PLP 139-151 and the clinical course of R-EAE. (C) 1998 Elsevier Science B.V.