Objective short sleep duration increases the risk of all-cause mortality associated with possible vascular cognitive impairment
Objective short sleep duration increases the risk of all-cause mortality associated with possible vascular cognitive impairment
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DOI：
10.1016/j.sleh.2019.09.003
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发表时间：
2020-02-01
期刊：
影响因子：
4.1
通讯作者：
Bixler, Edward O.
中科院分区：
文献类型：
--
作者：
Fernandez-Mendoza, Julio;He, Fan;Bixler, Edward O.
目的：认知障碍是世界范围内导致残疾的主要原因，心脏代谢性疾病是其发展的关键因素。睡眠不足也是大脑健康的一个潜在因素；然而，它在预测死亡率方面的作用仍然知之甚少。我们调查了客观的短睡眠时间是否增加了与认知障碍和心脏代谢疾病共存相关的所有原因死亡的风险，即可能的血管认知障碍(VCI)。设计：这是一项纵向研究。地点：这是一项基于人群的实验室研究。参与者：来自宾夕法尼亚州立大学成人队列的1,524名成年人(年龄48.9+/-13.4岁，53.4%女性)纳入研究。测量：在19.1+/-5.1年的随访后估计所有原因的死亡率。进行神经心理学测试以确定认知损害，临床病史和体格检查以确定2型高血压、2型糖尿病、心脏病和中风。在实验室中，可能的VCI被定义为存在这些心脏代谢疾病和认知障碍中的任何一种，进行8小时多导睡眠图(PSG)以确定睡眠时间(即，
Objectives: Cognitive impairment is a leading cause of disability worldwide, and cardiometabolic conditions are key contributors to its development. Short sleep is also a potential contributor to brain health; however, its role in predicting mortality remains poorly understood. We investigated whether objective short sleep duration increases the risk of all cause mortality associated with coexisting cognitive impairment and cardiometabolic conditions, i.e., possible vascular cognitive impairment (VCI).Design: This is a longitudinal study.Setting: This is a population-based, in-lab study.Participants: A total of 1,524 adults (aged 48.9 +/- 13.4 years, 53.4% women) from the Penn State Adult Cohort were included in the study.Measurements: All-cause mortality was estimated after 19.1 +/- 5.1 years of follow-up. Neuropsycholog cal testing was performed to ascertain cognitive impairment Clinical history and physical examination were performed to ascertain stage 2 hyperiension, type 2 diabeles, heart disease, and stroke. Possible VCI was defined as the presence of any of these cardiometabolic conditions and cognitive impairment In-lab, 8 hour polysomnography (PSG) was performed to ascertain shod sleep duration (i.e.,