Estimating the shell parameters of SonoVue microbubbles using light scattering.
Estimating the shell parameters of SonoVue microbubbles using light scattering.
复制标题
DOI：
10.1121/1.3242346
复制
发表时间：
2009-12
期刊：
影响因子：
--
通讯作者：
J. Tu;J. Guan;Yuanyuan Qiu;T. Matula
中科院分区：
文献类型：
--
作者：
J. Tu;J. Guan;Yuanyuan Qiu;T. Matula
实验测量了单个SonoVue微泡在脉冲超声作用下的动态响应。比较了三种常用的气泡动力学模型(即Hoff模型、Sarkar模型和线性化的Marmotant模型)，以确定最适合于实验数据的模型。根据发表的光学显微镜数据对这些模型进行了评估。这种比较表明，很难对这些模型进行排序，因为在这些条件下，这些模型中的壳参数是密切相关的。利用Marmotant模型的线性化版本从实验光散射数据中估计了SonoVue微泡的壳层参数(即剪切模数和剪切粘度)，作为环境微泡半径的函数。SonoVue微泡壳体弹性和膨胀粘度随周围气泡半径的增大而增大，与先前发表的数据一致。结果表明，光散射与几种流行的气泡动力学模型之一结合使用，在表征微泡响应和评估壳层参数方面是有效的。
Experiments were performed to measure the dynamical response of individual SonoVue microbubbles subjected to pulsed ultrasound. Three commonly used bubble dynamic models (i.e., Hoff's, Sarkar's, and linearized Marmottant's models) were compared to determine the most appropriate model for fitting to the experimental data. The models were evaluated against published optical microscopy data. The comparison suggests that it is difficult to rank these models for lipid-shelled microbubbles undergoing small-amplitude oscillations, because under these conditions the shell parameters in these models are closely related. A linearized version of the Marmottant model was used to estimate the shell parameters (i.e., shear modulus and shear viscosity) of SonoVue microbubbles from the experimental light scattering data, as a function of ambient microbubble radius. The SonoVue microbubble shell elasticity and dilatational viscosity increase with ambient bubble radius, in agreement with previously published data. The results suggest that light scattering, used in conjunction with one of several popular bubble dynamics models, is effective at characterizing microbubble response and evaluating shell parameters.