Incidence, clinical features and diagnosis of cicatrising conjunctivitis in Australia and New Zealand
Incidence, clinical features and diagnosis of cicatrising conjunctivitis in Australia and New Zealand
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DOI：
10.1038/s41433-018-0155-7
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发表时间：
2018-10-01
期刊：
影响因子：
3.9
通讯作者：
Watson, Stephanie
中科院分区：
文献类型：
--
作者：
Bobba, Samantha;Devlin, Connor;Watson, Stephanie
目的本研究旨在确定的发病率，临床特征和管理的瘢痕性结膜炎在澳大利亚和新西兰，也使比较与数据从UnitedKingdom.Methods的前瞻性监测研究进行了17个月以上，通过澳大利亚和新西兰眼科监测单位与一年的随访期。要求监测股数据库中的执业眼科医生每月报告最近诊断的瘢痕性结膜炎病例。最初和后续调查问卷被发送到眼科医生谁报告了阳性病例，以获得人口统计学和临床数据。根据研究期间报告的病例和人群数据计算瘢痕性结膜炎的最低发病率。结果在17个月的研究期间（2011年12月至2013年4月），报告了56例瘢痕性结膜炎。获得了35例病例（62%）的数据，平均年龄为74岁（范围：28-94岁）。最常见的病因是眼粘膜类天疱疮（n = 18例，51.4%）、Stevens-Johnson综合征（n = 3例，8.6%）和移植物抗宿主病（n = 3例，8.6%）。瘢痕性结膜炎在澳大利亚和新西兰的最低发病率为1.5每百万，可比的发病率数据从英国.Conclusions本研究是第一个前瞻性记录的瘢痕性结膜炎在澳大利亚和新西兰的发病率和第二个世界范围内。它提供了治疗眼科医生报告的瘢痕性结膜炎的人口统计学和管理的新数据。
Aims This study aimed to determine the incidence, clinical features and management of cicatrising conjunctivitis in Australia and New Zealand, also enabling comparison with data from the United Kingdom.Methods A prospective surveillance study was conducted over 17 months via the Australian and New Zealand Ophthalmic Surveillance Unit with a one-year follow-up period. Practicing ophthalmologists on the Surveillance Unit's database were asked to report recently diagnosed cases of cicatrising conjunctivitis on a monthly basis. Initial and follow-up questionnaires were sent to ophthalmologists who had reported positive cases to obtain demographic and clinical data. The minimum incidence of cicatrising conjunctivitis was calculated based on cases reported during the study period and from population data.Results During the 17-month study period (December 2011-April 2013), 56 cases of cicatrising conjunctivitis were reported. Data was obtained for 35 cases (62%) with a mean age of 74 years (range, 28-94 years). The most common aetiologies were ocular mucus membrane pemphigoid (n = 18 cases, 51.4%), Stevens-Johnson Syndrome (n = 3, 8.6%) and graft versus host disease (n = 3, 8.6%). The minimum incidence of cicatrising conjunctivitis in Australia and New Zealand was 1.5 per million, comparable to incidence data from the United Kingdom.Conclusions This study is the first to prospectively record the incidence of cicatrising conjunctivitis in Australia and New Zealand and the second worldwide. It provides novel data on demographics and management of cicatrising conjunctivitis, as reported by treating ophthalmologists.