Hepsin promotes prostate cancer progression and metastasis
Hepsin promotes prostate cancer progression and metastasis
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DOI：
10.1016/j.ccr.2004.07.008
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发表时间：
2004-08-01
期刊：
影响因子：
50.3
通讯作者：
Vasioukhin, V
中科院分区：
文献类型：
--
作者：
Klezovitch, O;Chevillet, J;Vasioukhin, V
大多数癌症相关死亡与转移有关；然而，人们对这一过程的机制知之甚少。Hepsin是一种细胞表面丝氨酸蛋白酶，在人类前列腺癌中显著上调；然而，这种上调的功能意义尚不清楚。我们在此报告体内前列腺上皮中hepsin的过度表达导致基底膜的紊乱。在非转移性前列腺癌小鼠模型中，hepsin的过表达对细胞增殖没有影响，但会导致基底膜的紊乱，促进原发性前列腺癌的进展和向肝、肺和骨的转移。我们提供的体内证据表明，原发性肿瘤中细胞表面丝氨酸蛋白酶的上调促进了癌症的进展和转移。
The majority of cancer-related deaths are associated with metastasis; however, little is known about the mechanisms of this process. Hepsin is a cell surface serine protease that is markedly upregulated in human prostate cancer; however, the functional significance of this upregulation is unknown. We report here that hepsin overexpression in prostate epithelium in vivo causes disorganization of the basement membrane. Overexpression of hepsin in a mouse model of nonmetastasizing prostate cancer has no impact on cell proliferation, but causes disorganization of the basement membrane and promotes primary prostate cancer progression and metastasis to liver, lung, and bone. We provide in vivo evidence that upregulation of a cell surface serine protease in a primary tumor promotes cancer progression and metastasis.