SELF-NONSELF DISCRIMINATION BY T-CELLS
SELF-NONSELF DISCRIMINATION BY T-CELLS
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DOI：
10.1126/science.1972594
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发表时间：
1990-06-15
期刊：
影响因子：
56.9
通讯作者：
KISIELOW, P
中科院分区：
文献类型：
--
作者：
VONBOEHMER, H;KISIELOW, P
αβ T 细胞受体 (TCR) 通过与抗原和 MHC 分子结合来识别由主要组织相容性复合体 (MHC) 编码的细胞表面分子呈递的抗原。自我与非自身抗原和 MHC 分子的区分是通过胸腺中 T 细胞的阴性和阳性选择来实现的：具有与自身抗原结合的受体的潜在有害 T 细胞以及自身 MHC 分子在它们能够发起免疫反应之前被删除。相反，具有结合外来抗原和自身MHC分子的受体的有用T细胞的成熟需要其受体在没有外来抗原的情况下与胸腺上皮上的MHC分子结合。 TCR 与 I 类或 II 类 MHC 分子的结合引导所选细胞分别分化为 CD4-8+（杀伤性）T 细胞或 CD4+8-（辅助性）T 细胞。
The αβ T cell receptor (TCR) recognizes antigens that are presented by major histocompatibility complex (MHC)-encoded cell surface molecules by binding to both the antigen and the MHC molecules. Discrimination of self from nonself antigens and MHC molecules is achieved by negative and positive selection of T cells in the thymus: potentially harmful T cells with receptors that bind to self antigens plus self MHC molecules are deleted before they can mount immune responses. In contrast, the maturation of useful T cells with receptors that bind foreign antigens plus self MHC molecules requires the binding of their receptor to MHC molecules on thymic epithelium in the absence of foreign antigen. The binding of the TCR to either class I or class II MHC molecules directs differentiation of the selected cells into either CD4-8+(killer) or CD4+8-(helper) T cells, respectively.