Aging-associated pancreatic exocrine insufficiency in the unanesthetized rat.
Aging-associated pancreatic exocrine insufficiency in the unanesthetized rat.
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未麻醉大鼠中与衰老相关的胰腺外分泌功能不全。
DOI：
10.1159/000212635
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发表时间：
1984
期刊：
影响因子：
3.5
通讯作者：
Dadufalza,VD
中科院分区：
文献类型：
--
作者：
Hollander,D;Dadufalza,VD
对个体的观察表明，胰腺功能可能会随着年龄的增长而减弱。为了探索这种可能性，我们测量了胰腺液，蛋白质和淀粉酶输出作为一个功能的老化大鼠。大鼠的手术准备包括胰腺分泌物的外部引流，而不阻塞正常的胆汁流动，并将胃酸完全转移出十二指肠，以防止内源性分泌素释放。在手术后24小时收集未麻醉动物的基础状态下的胰腺分泌物。蛋白质和淀粉酶产量最高，在3个月的年龄和下降到不到20%的最大值的27个月的年龄。例如，在3至27月龄之间，淀粉酶产量从4，354 U/h/kg降至105 U/h/kg，蛋白质产量从33.5 mg/h/kg降至1.7 mg/h/kg。我们的研究结果表明，大鼠的衰老与胰腺外分泌功能下降有关。建议进一步仔细评估老年人的胰腺功能。
Observations in individuals have suggested that pancreatic functions may be diminished with aging. In order to explore this possibility, we measured pancreatic fluid, protein and amylase output as a function of aging in the rat. Surgical preparations of the rats included external drainage of pancreatic secretions without obstructing normal bile flow and complete diversion of gastric acid out of the duodenum to prevent endogenous secretin release. Pancreatic secretions were collected in the basal state in unanesthetized animals 24 h after surgery. Protein and amylase output were highest at 3 months of age and decreased to less than 20% of maximal values by 27 months of age. For example, amylase output decreased from 4,354 to 105 U/h/kg and protein output fell from 33.5 to 1.7 mg/h/kg between 3 and 27 months of age. Our findings indicate that aging in the rat is associated with diminished pancreatic exocrine functions. Further careful assessment of pancreatic functions in aging individuals is advisable.