Inflammation markers and metabolic characteristics of subjects with 1-h plasma glucose levels.
Inflammation markers and metabolic characteristics of subjects with 1-h plasma glucose levels.
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DOI：
10.2337/dc09-1342
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发表时间：
2010-02
期刊：
影响因子：
16.2
通讯作者：
Rotella CM
中科院分区：
文献类型：
--
作者：
Bardini G;Dicembrini I;Cresci B;Rotella CM
评估1小时血糖（1hPG）和炎症与正常糖耐量（NGT）和糖尿病前期的关系。入组了1，062例受试者的队列。在口服葡萄糖负荷（口服葡萄糖耐量试验）后，我们比较了NGT和糖尿病前期高于和低于1hPG临界点（155 mg/dl）的受试者。测定亚临床炎症的纤维蛋白原和白细胞计数（白色血细胞[WBC]）、脂质比率、胰岛素敏感性（Matsuda指数）。NGT和糖尿病前期（1hPG >155 mg/dl）患者的炎性标志物和血脂比值显著升高（P < 0.05）。在年龄、性别和BMI校正分析中，1hPG与WBC计数和纤维蛋白原显著升高相关（P < 0.05）。1hPG升高组胰岛素敏感性显著低于<1hPG组（P < 0.01）。NGT和糖尿病前期受试者中1hPG升高与亚临床炎症、高血脂比和胰岛素抵抗相关。因此，1hPG >155 mg/dl可被认为是心血管风险的新“标志物”。
To assess the association of 1-h plasma glucose (1hPG) and inflammation with normal glucose tolerance (NGT) and pre-diabetes. A cohort of 1,062 subjects was enrolled. After oral glucose load (oral glucose tolerance test), we compared subjects with NGT and pre-diabetes above and below the 1hPG cut point (155 mg/dl). Fibrinogen and leukocytes count (white blood cells [WBCs]) for subclinical inflammation, lipid ratios, insulin sensitivity (Matsuda index) were determined. Patients with NGT and pre-diabetes (1hPG >155 mg/dl) showed a significant increase of inflammatory markers and lipid ratios (for all, P < 0.05). In age-, sex-, and BMI-adjusted analysis, 1hPG was associated with a significantly higher WBC count and fibrinogen (P < 0.05). Patients with elevated 1hPG showed a highly significant lower insulin sensitivity than subjects <1hPG (P < 0.01). Elevated 1hPG in subjects with NGT and pre-diabetes is associated with subclinical inflammation, high lipid ratios, and insulin resistance. Therefore, 1hPG >155 mg/dl could be considered a new “marker” for cardiovascular risk.