Universal structures of normal and pathological heart rate variability.
Universal structures of normal and pathological heart rate variability.
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DOI：
10.1038/srep21749
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发表时间：
2016-02-25
影响因子：
4.6
通讯作者：
Fajardo-López J
中科院分区：
文献类型：
--
作者：
Gañán-Calvo AM;Fajardo-López J
生物体的循环系统是一个自主的机械系统，与呼吸系统柔和地协调，两者都是通过进化发展起来的，作为对与运动相关的复杂氧气需求模式的反应。循环系统的健康植根于适应性，这需要固有的可变性。在这里，我们表明，一个广义的N维归一化图表示心率变异性揭示了两个普遍的mammic模式作为特定的签名的健康一个反映心脏的适应性，和其他的心脏呼吸频率调谐。此外，我们确定了至少三个普遍的药理学特征，其存在在病理条件下（心肌梗死;心力衰竭;和从猝死中恢复）与两个健康者成比例地损害。所识别的通用心脏结构的存在以及心率变异性图的质心的位置提供了对健康-病理梯度的独特定量评估。
The circulatory system of living organisms is an autonomous mechanical system softly tuned with the respiratory system, and both developed by evolution as a response to the complex oxygen demand patterns associated with motion. Circulatory health is rooted in adaptability, which entails an inherent variability. Here, we show that a generalized N-dimensional normalized graph representing heart rate variability reveals two universal arrhythmic patterns as specific signatures of health one reflects cardiac adaptability, and the other the cardiac-respiratory rate tuning. In addition, we identify at least three universal arrhythmic profiles whose presences raise in proportional detriment of the two healthy ones in pathological conditions (myocardial infarction; heart failure; and recovery from sudden death). The presence of the identified universal arrhythmic structures together with the position of the centre of mass of the heart rate variability graph provide a unique quantitative assessment of the health-pathology gradient.