Thyroid hormone receptors regulate adipogenesis and carcinogenesis via crosstalk signaling with peroxisome proliferator-activated receptors.
Thyroid hormone receptors regulate adipogenesis and carcinogenesis via crosstalk signaling with peroxisome proliferator-activated receptors.
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DOI：
10.1677/jme-09-0107
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发表时间：
2010-03
影响因子：
3.5
通讯作者：
Cheng SY
中科院分区：
文献类型：
--
作者：
Lu C;Cheng SY
过氧化物酶体增殖物激活受体（PPARs）和甲状腺激素受体（TRs）是核受体超家族的成员。它们是配体依赖性转录因子，与其启动子中的同源激素应答元件相互作用，以调节各自的靶基因表达，从而调节细胞功能。虽然每种蛋白的转录活性都受其各自配体的调节，但最近的研究表明，PPARs和TRs通过多种机制相互作用以影响不同的生物学功能。在这里，我们回顾了最近的进展，了解这两个重要的核受体之间的串扰的分子机制和生物学影响，重点是它们在脂肪形成和癌变中的作用。
Peroxisome proliferator-activated receptors (PPARs) and thyroid hormone receptors (TRs) are members of the nuclear receptor superfamily. They are ligand-dependent transcription factors that interact with their cognate hormone response elements in the promoters to regulate respective target gene expression to modulate cellular functions. While the transcription activity of each is regulated by their respective ligands, recent studies indicate that via multiple mechanisms PPARs and TRs crosstalk to affect diverse biological functions. Here, we review recent advances in the understanding of the molecular mechanisms and biological impact of crosstalk between these two important nuclear receptors, focusing on their roles in adipogenesis and carcinogenesis.