Circulating GDF11 levels are decreased with age but are unchanged wan obesity and type 2 diabetes
Circulating GDF11 levels are decreased with age but are unchanged wan obesity and type 2 diabetes
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DOI：
10.18632/aging.101865
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发表时间：
2019-03-31
期刊：
影响因子：
5.2
通讯作者：
Gomez-Ambrosi, Javier
中科院分区：
文献类型：
--
作者：
Anon-Hidalgo, Juan;Catalan, Victoria;Gomez-Ambrosi, Javier
生长分化因子11（GDF 11）是转化生长因子β（TGF β）超家族的成员，其随着年龄的增长而下降，并在小鼠骨骼肌中发挥抗衰老再生作用。然而，最近在人类和小鼠中的数据相互矛盾，使人们对其真正的功能作用产生怀疑。本研究的目的是比较不同年龄、体重和血糖状态个体中GDF 11的循环浓度。通过ELISA法测定319名受试者的GDF 11血清浓度。在41-50岁组的人群中，GDF 11浓度显著增加，而在老年组中则下降（61-70岁和71-80岁组，所有年龄组之间的比较P=0.008）。然而，观察到无脂肪质量指数（FFMI）（用于估计与身高相关的肌肉质量量的公式）与IogGDF 11之间没有显著相关性（r=0.08，P=0.197）。此外，没有发现关于肥胖或血糖状态的GDF 11的循环浓度的显著差异。进一步的研究应该确定GDF 11在衰老中的确切病理生理作用。
Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor beta (TGF beta) superfamily which declines with age and exerts anti-aging regenerative effects in skeletal muscle in mice. However, recent data in humans and mice are conflicting casting doubts about its true functional actions. The aim of the present study was to compare the circulating concentrations of GDF11 in individuals of different ages as well as body weight and glycemic status. Serum concentrations of GDF11 were measured by ELISA in 319 subjects. There was a significant increase in GDF11 concentrations in people in the 41-50 y group and a decline in the elder groups (61-70 and 71-80 y groups, P=0.008 for the comparison between all age groups). However, no significant correlation between fat-free mass index (FFMI), a formula used to estimate the amount of muscle mass in relation to height, and IogGDF11 was observed (r=0.08, P=0.197). Moreover, no significant differences in circulating concentrations of GDF11 regarding obesity or glycemic status were found. Serum GDF11 concentrations in humans decrease in older ages being unaltered in obesity and T2D. Further studies should determine the exact pathophysiological role of GDF11 in aging.