Prenatal maternal depression is associated with low birth weight through shorter gestational age in term infants in Korea.
Prenatal maternal depression is associated with low birth weight through shorter gestational age in term infants in Korea.
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DOI：
10.1016/j.earlhumdev.2013.11.006
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发表时间：
2014-01
影响因子：
2.5
通讯作者：
Shin YJ
中科院分区：
文献类型：
--
作者：
Chang HY;Keyes KM;Lee KS;Choi IA;Kim SJ;Kim KW;Shin YH;Ahn KM;Hong SJ;Shin YJ
母亲产前抑郁症与后代出生体重较低有关，但胎龄对这种关联的影响仍不清楚。我们的目的是调查产前抑郁症对低出生体重、胎龄和足月胎龄体重的影响。前瞻性队列研究。数据收集自 691 名妊娠晚期妇女，她们足月产下单胎，没有围产期并发症。 152 名女性的流行病学研究中心抑郁量表 10 评分≥10，并被归类为产前抑郁。低出生体重（<2500 克）、出生胎龄和胎龄出生体重百分位。与产前非抑郁女性的后代相比，产前抑郁女性的后代更有可能出现低出生体重（比值比 [OR] 2.94，95% 置信区间 [CI] 1.14–7.58），但根据胎龄进行调整后，这种关联性减弱（OR 1.66，95% CI 0.55–5.02）。产前抑郁妇女的后代的孕周数低于产前非抑郁妇女的后代（胎龄增加一周的 OR：0.66，95% CI 0.47-0.93）。产前抑郁症与胎龄出生体重百分位数之间没有关联。产前抑郁症与足月低出生体重无关，但与胎龄相关，这表明母亲抑郁症与出生体重之间的关联可能反映了抑郁症对后代胎龄的影响。
Maternal prenatal depression is associated with lower offspring birth weight, yet the impact of gestational age on this association remains inadequately understood. We aimed to investigate the effect of prenatal depression on low birth weight, gestational age, and weight for gestational age at term. Prospective cohort study. Data were collected from 691 women in their third trimester of pregnancy who went on to give birth to a singleton at term without perinatal complications. One hundred and fifty-two women had a Center for Epidemiologic Studies Depression Scale-10 score ≥10 and were classed as prenatally depressed. Low birth weight (<2500 g), gestational age at birth, and birth weight percentile for gestational age. Offspring of prenatally depressed women were more likely to be low birth weight (Odds ratio [OR] 2.94, 95% confidence interval [CI] 1.14–7.58) than offspring of prenatally non-depressed women, but the association was attenuated (OR 1.66, 95% CI 0.55–5.02) when adjusted for gestational age. Offspring of prenatally depressed women had lower gestational age in weeks (OR for one week increase in gestational age: 0.66, 95% CI 0.47–0.93) than offspring of prenatally non-depressed women. There was no association between prenatal depression and birth weight percentile for gestational age. Prenatal depression was not associated with low birth weight at term, but was associated with gestational age, suggesting that association between maternal depression and birth weight may be a reflection of the impact of depression on offspring gestational age.