Genetic Control of the Antibody Response: Relationship between Immune Response and Histocompatibility (H-2) Type
Genetic Control of the Antibody Response: Relationship between Immune Response and Histocompatibility (H-2) Type
复制标题
抗体反应的遗传控制：免疫反应与组织相容性（H-2）类型之间的关系
作者：
H. Mcdevitt;A. Chinitz
近交系小鼠对一系列相关的合成多肽抗原的免疫应答是一种遗传控制性状，与主要组织相容性位点（H-2）的基因型密切相关。相同H-2型的所有菌株表现出相同的免疫反应模式，与给定菌株的遗传背景的其余部分无关。不同H-2型菌株的应答模式存在明显的抗原特异性多态性。
The immune responses of inbred mice to a related series of three synthetic polypeptide antigens are genetically controlled traits which are closely correlated with the genotype for the major histocompatibility (H-2) locus. All strains of the same H-2 type exhibit the same pattern of immune response, independent of the remainder of a given strain's genetic background. There is marked antigen-specific polymorphism between strains of different H-2 types with respect to their patterns of response.