Motor neuron columnar fate imposed by sequential phases of Hox-c activity
Motor neuron columnar fate imposed by sequential phases of Hox-c activity
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DOI：
10.1038/nature02051
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发表时间：
2003-10-30
期刊：
影响因子：
64.8
通讯作者：
Jessell, TM
中科院分区：
文献类型：
--
作者：
Dasen, JS;Liu, JP;Jessell, TM
神经元成柱组织是中枢神经系统结构和功能的一个显著特征。在中枢神经系统的许多区域，神经元成列的分组将细胞体位置与轴突轨迹联系起来，从而有助于建立神经地形图。这种联系在发育中的脊髓中很突出，在那里柱状运动神经元组支配周围不同的目标。我们在这里表明，Hox-c蛋白表达和活性的顺序阶段控制脊髓运动神经元的柱状分化。Hox在神经祖细胞中的表达是通过分级成纤维细胞生长因子信号传导建立的，并转化为不同的运动神经元Hox模式。然后运动神经元柱状命运通过Hox蛋白的细胞自主抑制和激活功能出现。Hox蛋白还指导建立运动地形投射的基因表达，因此暗示Hox蛋白是脊髓运动神经元身份和组织的关键决定因素。
The organization of neurons into columns is a prominent feature of central nervous systemstructure and function. In many regions of the central nervous system the grouping of neurons into columns links cell-body position to axonal trajectory, thus contributing to the establishment of topographic neural maps. This link is prominent in the developing spinal cord, where columnar sets of motor neurons innervate distinct targets in the periphery. We show here that sequential phases of Hox-c protein expression and activity control the columnar differentiation of spinal motor neurons. Hox expression in neural progenitors is established by graded fibroblast growth factor signalling and translated into a distinct motor neuron Hox pattern. Motor neuron columnar fate then emerges through cell autonomous repressor and activator functions of Hox proteins. Hox proteins also direct the expression of genes that establish motor topographic projections, thus implicating Hox proteins as critical determinants of spinal motor neuron identity and organization.