Correlations between alveolar bone microstructure and bone turnover markers in pre- and post-menopausal women
Correlations between alveolar bone microstructure and bone turnover markers in pre- and post-menopausal women
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DOI：
10.1016/j.oooo.2011.10.028
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发表时间：
2013-04-01
影响因子：
2.9
通讯作者：
Ejiri, Sadakazu
中科院分区：
文献类型：
--
作者：
Yamashita-Mikami, Emi;Tanaka, Mikako;Ejiri, Sadakazu
客观的。在牙种植体制备过程中提取牙槽松质骨活检样本，用于研究更年期引起的微观结构变化以及这些变化与骨转换标志物之间的关系。研究设计。受试者为 18 名接受下颌种植体的女性：绝经前 (n = 5)、绝经后早期 (5 岁；n = 10)。使用显微计算机断层扫描和 3 维骨形态测量仪测量骨转换标志物并分析样本。结果。绝经后期女性的牙槽骨体积明显少于绝经前女性。与绝经前女性相比，绝经后早期女性的小梁更加分离且呈杆状（P < .05）。每个牙槽骨参数与至少 1 个骨转换标志物显着相关 (P < .05)。结论。即使在绝经后早期的女性中，牙槽松质骨结构也开始发生变化，并且这种结构的变化与骨转换标志物密切相关。 (Oral Surg Oral Med Oral Pathol Oral Radiol 2013;115:e12-e19)
Objective. Alveolar cancellous bone biopsy samples were extracted during dental implant preparation for investigating microstructural changes due to menopause and relationships between these changes and bone turnover markers.Study Design. Subjects were 18 women receiving mandibular implants: premenopausal (n = 5), early postmenopausal (5 years; n = 10). Bone turnover markers were measured and the samples analyzed using microscopic computerized tomography and 3-dimensional bone morphometry.Results. The alveolar bone volume was significantly less in late postmenopausal women than in premenopausal ones. The trabeculae in early postmenopausal women were more separated and rod-like than in premenopausal ones (P < .05). Each alveolar bone parameter was significantly (P < .05) related to at least 1 bone turnover marker.Conclusions. Alveolar cancellous bone structure begins changing even in early postmenopausal women, and this structure varies in close relationship to bone turnover markers. (Oral Surg Oral Med Oral Pathol Oral Radiol 2013;115:e12-e19)