The Mackenzie Davidson Memorial Lecture: Detection of small changes to the brain with serial magnetic resonance imaging
The Mackenzie Davidson Memorial Lecture: Detection of small changes to the brain with serial magnetic resonance imaging
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DOI：
10.1259/0007-1285-68-816-1271
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发表时间：
1995-12-01
影响因子：
2.6
通讯作者：
Bydder, GM
中科院分区：
文献类型：
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作者：
Bydder, GM
本文描述了使用连续磁共振图像的亚体素配准来检测大脑及其周围组织和液体的微小变化，并阐述了该技术在生理和临床问题中的应用。在正常受试者和患者中，在两次或更多次（包括造影剂增强前后）获取了各向同性的T - 1加权容积图像。对图像进行分割，并使用正弦插值进行三维刚体平移和旋转，通过卡方（χ²）检验和最小化程序精确匹配图像。以这种方式生成的精确配准图像以及由此衍生的减影图像被用于检测大脑的变化。描述了一种基于识别组织或液体信号强度以及部位、形状和大小变化的图像解读系统。使用一个基于高、低信号强度两个平台及其之间边界区域概念的简单模型来分析位置变化。在正常受试者中观察到由于头部方向差异以及吸入氧气、二氧化碳和碳合气所导致的微小变化。在头部外伤、星形细胞瘤和多发性硬化症患者中也观察到了变化。观察到了由于造影剂增强和治疗所导致的差异。此外，儿童因生长发育而出现变化。
The use of subvoxel registration of serial magnetic resonance images to detect small changes to the brain and its surrounding tissues and fluids is described and the application of this technique to physiological and clinical problems is illustrated. Isotropic T-1 weighted volume images were obtained in normal subjects and patients on two or more occasions (including pre- and post-contrast enhancement). The images were segmented and three-dimensional rigid body translation and rotation were used with sine interpolation to match precisely the images using a chi(2) test and a minimization routine. Accurately registered images produced in this way, as well as subtraction images derived from them, were used to detect change to the brain. A system of image interpretation based on recognition of changes in tissue or fluid signal intensity as well as site, shape and size is described. Changes in position are analysed using a simple model based on the concept of two plateaux of higher and lower signal intensities and a border zone between them. Small changes due to differences in orientation of the head, as well as inhalation of oxygen, carbon dioxide and carbogen were observed in normal subjects. Changes were also observed in patients with head trauma, an astrocytoma and multiple sclerosis. Differences due to contrast enhancement and treatment were seen. In addition, children showed changes due to growth and development.