Intracellularly Acid-Switchable Multifunctional Micelles for Combinational Photo/Chemotherapy of the Drug-Resistant Tumor
Intracellularly Acid-Switchable Multifunctional Micelles for Combinational Photo/Chemotherapy of the Drug-Resistant Tumor
复制标题
细胞内酸可切换多功能胶束用于耐药肿瘤的光/化疗联合治疗
DOI：
10.1021/acsnano.5b07706
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发表时间：
2016-03-01
期刊：
影响因子：
17.1
通讯作者：
Li, Yaping
中科院分区：
文献类型：
--
作者：
Wang, Tingting;Wang, Dangge;Li, Yaping
固有或获得性耐药是当今癌症化疗的主要挑战。到目前为止，许多纳米药物递送系统（NDDS）已被用于对抗癌症耐药性。然而，由于实体瘤中生理和病理屏障的存在，目前NDDS的治疗效果受到纳米颗粒有限的肿瘤渗透的严重影响。在这项研究中，我们报告的设计和制造的细胞内酸开关的多功能胶束相结合的光和化疗的耐药肿瘤。胶束由pH响应性二嵌段共聚物、光敏剂和阿霉素的聚合物前药组成。胶束在血液循环过程中显示出沉默的荧光和光活性，并在弱酸性条件下转换为活性状态（即，pH
The intrinsic or acquired drug resistance is the main challenge for cancer chemotherapy today. So far, many nanosized drug delivery systems (NDDS) have been exploited to combat cancer drug resistance. However, the therapy efficacy of current NDDS is severely impaired by the limited tumor penetration of the nanoparticles due to the existence of physiological and pathological barriers in the solid tumor. In this study, we report on the design and fabrication of intracellularly acid-switchable multifunctional micelles for combinational photo- and chemotherapy of the drug-resistant tumor. The micelles were composed of a pH-responsive diblock copolymer, a photosensitizer, and a polymeric prodrug of doxorubicin. The micelle displayed silenced fluorescence and photoactivity during the blood circulation and switched to an active state in weakly acid conditions (i.e., pH