An Information-Theoretical Approach for Calcium Signaling Specificity.
An Information-Theoretical Approach for Calcium Signaling Specificity.
复制标题
钙信号特异性的信息理论方法。
DOI：
10.1109/tnb.2018.2882223
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发表时间：
2019
影响因子：
3.9
通讯作者：
Martins TV
中科院分区：
文献类型：
--
作者：
Martins TV
钙是动植物体内重要的信号传导因子。它参与了一系列过程的调节，这导致了钙信号如何激活刺激特异性反应的问题。我们介绍了一个计算框架，研究细胞内钙信号使用信息理论的元素。我们使用互信息来量化响应不同钙信号的蛋白质的差异激活，以提供特异性的操作定义。使用优化程序，该框架允许我们探索钙解码的生化决定因素。我们探索简单的玩具模型和一般结合动力学方法来证明所提出的框架的实用性和局限性。揭示信号特异性是理解细胞内信息处理的关键，也是未来设计用于分子通信的合成纳米器件的关键。
Calcium is a key signaling agent in animals and plants. Its involvement in the regulation of a wide range of processes has led to the question of how calcium signals can activate stimulus-specific responses. We introduce a computational framework for studying intracellular calcium signaling using elements of information theory. We use mutual information to quantify the differential activation of proteins in response to different calcium signals to provide an operational definition of specificity. Using optimization procedures this framework allows us to explore the biochemical determinants of calcium decoding. We explore simple toy models and general binding kinetics approaches to demonstrate the utility and limitations of the proposed framework. Unravelling signaling specificity is key for understanding information processing within cells and for the future design of synthetic nanodevices for molecular communications.