Frontoparietal network involved in successful retrieval from episodic memory. Spatial and temporal analyses using fMRI and ERP
Frontoparietal network involved in successful retrieval from episodic memory. Spatial and temporal analyses using fMRI and ERP
复制标题
DOI：
10.1093/cercor/bhl040
复制
发表时间：
2006-09-01
期刊：
影响因子：
3.7
通讯作者：
Sadato, Norihiro
中科院分区：
文献类型：
--
作者：
Iidaka, Tetsuya;Matsumoto, Atsushi;Sadato, Norihiro
神经基础的成功识别以前研究的项目，被称为“检索成功”，已被调查使用神经成像或脑电位，但是，很少有研究使用这两种方式。我们的研究结合了事件相关功能磁共振成像（fMRI）和事件相关电位（ERP）在不同的受试者组。神经反应进行了测量，而受试者进行了旧/新的识别任务与图片，以前已经研究过的深度或浅编码条件。功能磁共振成像实验表明，在参与提取成功的额顶区域中，额下回和顶内沟对有意识的回忆至关重要，因为这些区域的活动受到编码时记忆深度的影响。右顶叶区域对重复项目的反应受到重复滞后的调制，这表明该区域对基于熟悉度的判断至关重要。结构方程模型的结果显示，大脑左半球各区域之间的功能连通性比右半球更显著。ERP实验和独立成分分析的结果与fMRI实验的结果一致，表明重复项目产生的峰值比命中项目早约50 ms。
The neural basis for successful recognition of previously studied items, referred to as "retrieval success," has been investigated using either neuroimaging or brain potentials; however, few studies have used both modalities. Our study combined event-related functional magnetic resonance imaging (fMRI) and event-related potential (ERP) in separate groups of subjects. The neural responses were measured while the subjects performed an old/new recognition task with pictures that had been previously studied in either a deep- or shallow-encoding condition. The fMRI experiment showed that among the frontoparietal regions involved in retrieval success, the inferior frontal gyrus and intraparietal sulcus were crucial to conscious recollection because the activity of these regions was influenced by the depth of memory at encoding. The activity of the right parietal region in response to a repeated item was modulated by the repetition lag, indicating that this area would be critical to familiarity-based judgment. The results of structural equation modeling revealed that the functional connectivity among the regions in the left hemisphere was more significant than that in the right hemisphere. The results of the ERP experiment and independent component analysis paralleled those of the fMRI experiment and demonstrated that the repeated item produced an earlier peak than the hit item by approximately 50 ms.