Myopia Stabilization and Associated Factors Among Participants in the Correction of Myopia Evaluation Trial (COMET)
Myopia Stabilization and Associated Factors Among Participants in the Correction of Myopia Evaluation Trial (COMET)
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DOI：
10.1167/iovs.13-12403
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发表时间：
2013-12-01
影响因子：
4.4
通讯作者：
Zhang, Qinghua
中科院分区：
文献类型：
--
作者：
Dong, Li Ming;Fazzari, Melissa;Zhang, Qinghua
目的。使用Gompertz函数来估计近视稳定时的年龄和近视数量，并评估近视矫正评估试验（COMET）队列中的相关因素，该队列是一个大的不同种族的近视儿童群体。COMET招募了469名不同种族的儿童，年龄在6至12岁以下，球面等效折射在-1.25至-4.50屈光度(D)之间。非睫状体麻痹性屈光在4年内每半年测量一次，此后每年测量一次。通过至少6年的随访和11年的至少7次屈光测量，右眼数据符合个体Gompertz功能。用非线性最小二乘法估计函数参数。采用线性回归对相关因素进行评价。总共有426名参与者（91%）具有有效的Gompertz曲线拟合。近视稳定时的平均（SD）年龄为15.61（4.17）岁，近视稳定时的平均（SD）度数为-4.87 (2.01)d。种族（P < 0.0001）与近视稳定时的年龄无关，性别和近视父母的数量与近视稳定时的年龄无关。种族（P = 0.02）和父母近视数量（P = 0.01）与稳定时近视度数相关，而与性别无关。稳定时，非裔美国人最年轻（平均年龄13.82岁），近视程度最低（平均-4.36 D）。父母双方都近视的参与者与没有近视的参与者在稳定时的近视程度大约高出1.00 D。年龄与稳定时近视度数相关（r = -0.60, P < 0.0001）。Gompertz函数提供了不同种族人群中稳定近视的年龄和数量的估计值。这些发现应该为近视的时间进程以及干预措施的类型和时机的决定提供指导。
PURPOSE. To use the Gompertz function to estimate the age and the amount of myopia at stabilization and to evaluate associated factors in the Correction of Myopia Evaluation Trial (COMET) cohort, a large ethnically diverse group of myopic children.METHODS. The COMET enrolled 469 ethnically diverse children aged 6 to younger than 12 years with spherical equivalent refraction between -1.25 and -4.50 diopters (D). Noncycloplegic refraction was measured semiannually for 4 years and annually thereafter. Right eye data were fit to individual Gompertz functions in participants with at least 6 years of follow-up and at least seven refraction measurements over 11 years. Function parameters were estimated using a nonlinear least squares procedure. Associated factors were evaluated using linear regression.RESULTS. In total, 426 participants (91%) had valid Gompertz curve fits. The mean (SD) age at myopia stabilization was 15.61 (4.17) years, and the mean (SD) amount of myopia at stabilization was -4.87 (2.01) D. Ethnicity (P < 0.0001) but not sex or the number of myopic parents was associated with the age at stabilization. Ethnicity (P = 0.02) and the number of myopic parents (P = 0.01) but not sex were associated with myopia magnitude at stabilization. At stabilization, African Americans were youngest (mean age, 13.82 years) and had the least myopia (mean, -4.36 D). Participants with two versus no myopic parents had approximately 1.00 D more myopia at stabilization. The age and the amount of myopia at stabilization were correlated (r = -0.60, P < 0.0001).CONCLUSIONS. The Gompertz function provides estimates of the age and the amount of myopia at stabilization in an ethnically diverse cohort. These findings should provide guidance on the time course of myopia and on decisions regarding the type and timing of interventions.