ATROPHY OF MEDIAL TEMPORAL LOBES ON MRI IN PROBABLE ALZHEIMERS-DISEASE AND NORMAL AGING - DIAGNOSTIC-VALUE AND NEUROPSYCHOLOGICAL CORRELATES
ATROPHY OF MEDIAL TEMPORAL LOBES ON MRI IN PROBABLE ALZHEIMERS-DISEASE AND NORMAL AGING - DIAGNOSTIC-VALUE AND NEUROPSYCHOLOGICAL CORRELATES
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DOI：
10.1136/jnnp.55.10.967
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发表时间：
1992-10-01
影响因子：
11
通讯作者：
VALK, J
中科院分区：
文献类型：
--
作者：
SCHELTENS, P;LEYS, D;VALK, J
磁共振成像（MRI）显示，与对照组相比，阿尔茨海默病患者的内侧颞叶和海马体积大幅减少。定量体积测量尚未可用于常规临床用途。我们研究了 MRI 平片上内侧颞叶萎缩 (MTA) 的视觉评估是否可以区分阿尔茨海默病患者 (n = 21) 和年龄匹配的对照者 (n = 21)。 MTA 的程度通过排序程序确定，并通过内侧颞叶的线性测量（包括海马结构和脑脊液占据的周围空间）进行验证。阿尔茨海默病患者的主观评估 MTA 程度显着高于对照组（p = 0.0005）。线性测量与 MTA 的主观评估高度相关，并且组间也显示出显着差异。心室指数在各组之间没有显着差异。在阿尔茨海默病患者中，MTA 程度与简易精神状态检查和记忆测试的分数显着相关，但与精神速度测试的分数相关性较差。这项研究表明，使用普通 MRI 胶片可以快速、轻松地评估 MTA。 MRI 上显示的 MTA 强烈支持阿尔茨海默氏病的临床诊断，与记忆功能有关，并且似乎比全身性脑萎缩更早发生在疾病过程中。
Magnetic resonance imaging (MRI) has shown a great reduction in medial temporal lobe and hippocampal volume of patients with Alzheimer's disease as compared to controls. Quantitative volumetric measurements are not yet available for routine clinical use. We investigated whether visual assessment of medial temporal lobe atrophy (MTA) on plain MRI films could distinguish patients with Alzheimer's disease (n = 21) from age matched controls (n = 21). The degree of MTA was ascertained with a ranking procedure and validated by linear measurements of the medial temporal lobe including the hippocampal formation and surrounding spaces occupied by cerebrospinal fluid.Patients with Alzheimer's disease showed a significantly higher degree of subjectively assessed MTA than controls (p = 0.0005). Linear measurements correlated highly with subjective assessment of MTA and also showed significant differences between groups. Ventricular indices did not differ significantly between groups. In Alzheimer's disease patients the degree of MTA correlated significantly with scores on the mini-mental state examination and memory tests, but poorly with mental speed tests. This study shows that MTA may be assessed quickly and easily with plain MRI films. MTA shown on MRI strongly supports the clinical diagnosis of Alzheimer's disease, is related to memory function, and seems to occur earlier in the disease process than does generalised brain atrophy.