SINGLE NERVE CAPSAICIN - EFFECTS ON PAIN AND MORPHINE ANALGESIA IN THE FORMALIN AND FOOT-FLICK TESTS
SINGLE NERVE CAPSAICIN - EFFECTS ON PAIN AND MORPHINE ANALGESIA IN THE FORMALIN AND FOOT-FLICK TESTS
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DOI：
10.1016/0006-8993(84)90817-5
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发表时间：
1984-01-01
期刊：
影响因子：
2.9
通讯作者：
MELZACK, R
中科院分区：
文献类型：
--
作者：
ABBOTT, FV;GRIMES, RW;MELZACK, R
应用辣椒素对坐骨神经减少对疼痛的反应在脚轻弹测试，检查短暂的，阈值水平的疼痛。试图确定是否在福尔马林测试中发生类似的减少，该测试用于检查持续数小时的超阈深度疼痛。暴露大鼠一侧坐骨神经，在辣椒素溶液中浸泡15 min，结扎并切开隐神经。术后2天至12周后，用和不用吗啡对手术足进行福尔马林疼痛敏感性测试和足部轻弹测试。辣椒素治疗在手术后的任何时候都显著降低了对足部热痛的敏感性。在福尔马林测试中，影响很小，表明大鼠感受到的疼痛更多而不是更少。辣椒素治疗显著降低了福尔马林试验疼痛对吗啡的敏感性。效果出现了。术后1周并持续12周。辣椒素敏感的无髓鞘传入事件在阈值水平、非损伤性热痛中发挥作用，但不参与由组织损伤引起的疼痛。这些事件似乎对吗啡对这种类型疼痛的脊髓作用很重要。
Application of capsaicin to the sciatic nerve reduces responsiveness to pain in the foot-flick test which examines brief, threshold-level pain. An attempt was made to determine whether a similar reduction occurs in the formalin test which examines suprathreshold, deep pain that persists for several hours. The sciatic nerve on one side in the rat was exposed and soaked for 15 min in a solution of capsaicin and the saphenous nerve was ligated and cut. The operated foot was tested for sensitivity to pain in the formalin and foot-flick tests 2 days to 12 wk later both with and without morphine. The capsaicin treatment produced a substantial reduction in sensitivity to foot-flick heat pain at all times after surgery. In the formalin test, the effects were small and suggest the rats felt more rather than less pain. The capsaicin treatment markedly reduced the sensitivity of formalin test pain to morphine. The effect appeared .apprx. 1 wk after surgery and persisted for 12 wk. Capsaicin-sensitive unmyelinated afferents play a role in the threshold-level, non-damaging heat pain, but are not involved in pain resulting from tissue damage. These afferents appear to be important for the spinal action of morphine on this type of pain.