Continued inhibition of atherosclerotic lesion development in long term Western diet fed CD36°/apoE° mice
Continued inhibition of atherosclerotic lesion development in long term Western diet fed CD36°/apoE° mice
复制标题
DOI：
10.1016/j.atherosclerosis.2006.07.015
复制
发表时间：
2007-05-01
期刊：
影响因子：
5.3
通讯作者：
Febbraio, Maria
中科院分区：
文献类型：
--
作者：
Guy, Ella;Kuchibhotla, Sai;Febbraio, Maria
我们之前确定，在12周的apoE度小鼠中，CD36的缺失抑制了动脉粥样硬化病变的发展，这主要是由于巨噬细胞CD36的缺失。在疾病的后期，由于病变发展的进行性和其他因素的参与，这种效果可能会消失。然而，病变的发展仍然以巨噬细胞的募集和泡沫细胞的形成为特征，因此由于缺乏CD36而导致的脂质积累的延迟也可能继续延缓病变的发展。本研究的目的是确定缺乏CD36是否继续抑制病变的形成。背景匹配的apoE度和CD36度/apoE度小鼠喂食西方饮食长达35周。CD36度/apoE度小鼠在20周和35周时，病变面积分别减少25%和35%。最令人印象深刻的是35周时主动脉的大体外观差异：apoE度小鼠的主动脉硬化，几乎被病变阻塞，而CD36度/apoE度小鼠的主动脉病变较小，点状更明显。我们得出结论，在apoE度模型中，即使在疾病的晚期，CD36的缺失也会继续减轻病变负担。2006爱思唯尔爱尔兰有限公司版权所有。
We previously determined that absence of CD36 inhibited atherosclerosis lesion development in 12-week Western diet fed apoE degrees mice, and this was due largely to absence of macrophage CD36. It is possible that at later stages of disease this effect would be lost due to the progressive nature of lesion development and involvement of other factors. However, lesion development continues to be characterized by recruitment of macrophages and foam cell formation, thus it is also possible that delay in lipid accumulation as a result of absence of CD36 would continue to retard lesion development. The objective of this study was to determine if absence of CD36 continued to inhibit lesion formation. Background matched apoE degrees and CD36 degrees/apoE degrees mice were fed a Western diet for up to 35 weeks. At 20 and 35 weeks, lesion area was 25 and 35% less, respectively, in CD36 degrees/apoE degrees mice. Most impressive was the difference in gross appearance of the aortas at 35 weeks: apoE degrees aortas were sclerotic and nearly occluded by lesion, whereas aortas from CD36 degrees/apoE degrees mice had smaller lesions that were more punctate. We conclude that absence of CD36 continues to reduce lesion burden even at late stages of disease in the apoE degrees model. (c) 2006 Elsevier Ireland Ltd. All rights reserved.