ARE THERE STRUCTURAL AND FUNCTIONAL MODULES IN THE VERTEBRATE OLFACTORY-BULB
ARE THERE STRUCTURAL AND FUNCTIONAL MODULES IN THE VERTEBRATE OLFACTORY-BULB
复制标题
DOI：
10.1002/jemt.1070240207
复制
发表时间：
1993-02-01
影响因子：
2.5
通讯作者：
CINELLI, AR
中科院分区：
文献类型：
--
作者：
KAUER, JS;CINELLI, AR
许多不同的记录方法表明，气味剂引起的神经元活动模式广泛分布在脊椎动物嗅觉系统中嗅觉受体上皮细胞、嗅球和梨状皮层的细胞中。这些发现表明，气味分子的物理化学性质是通过在嗅觉回路中并行激活的分布式编码机制来处理的，以便表征单一的“单分子”气味剂。这些发现还表明，在较高水平上看到的反应模式是由嗅觉上皮外周受体细胞的差异反应建立的。理解这种所提出的编码方案的细节的一个要求是气味产生的模式与这些电路的组件的相关性。在本文中，2-脱氧葡萄糖和电压敏感染料研究的结果表明，这些反应的某些成分可能与在可重复识别的球细胞聚集体中建立的模式有关。这些发现与之前的观察结果一致，表明肾小球周围、二尖瓣/簇状和颗粒细胞的柱状细胞群，方向垂直于球茎层，在功能上彼此相关。当并行激活时，此类细胞组或模块可以作为完整整体响应的构建块组件。根据这一假设，不同组的此类模块将被不同的气味刺激激活，并且模块可以共享到不同刺激的物理化学性质重叠的程度。
A number of different recording methods have shown that odorants elicit patterns of neuronal activity widely distributed across cells of the olfactory receptor epithelium, olfactory bulb, and piriform cortex in the vertebrate olfactory system. These findings suggest that the physicochemical properties of odorant molecules are processed by distributed coding mechanisms activated in parallel in olfactory circuits in order to characterize a single, ''monomolecular'' odorant. These findings also suggest that the response patterns seen at higher levels are set up by differential responses in peripheral receptor cells of the olfactory epithelium. One requirement for understanding the details of this proposed encoding scheme is correlation of odor-generated patterns with the components of these circuits. In this paper, results from 2-deoxyglucose and voltage-sensitive dye studies suggest that certain components of these responses may relate to patterns established in reproducibly identifiable aggregates of bulbar cells. These findings are consistent with previous observations suggesting that columnar groups of periglomerular, mitral/tufted and granule cells, oriented perpendicular to the laminae of the bulb, are functionally related to one another. Such cell groups or modules, when activated in parallel, could serve as building block components of the complete ensemble response. According to this hypothesis, different sets of such modules would be activated with different odorant stimuli and modules could be shared to the degree to which the physicochemical properties of the different stimuli overlap.