Serum Resistin Concentrations and Risk of New Onset Heart Failure in Older Persons The Health, Aging, and Body Composition (Health ABC) Study
Serum Resistin Concentrations and Risk of New Onset Heart Failure in Older Persons The Health, Aging, and Body Composition (Health ABC) Study
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DOI：
10.1161/atvbaha.109.186783
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发表时间：
2009-07-01
影响因子：
8.7
通讯作者：
Harris, Tamara B.
中科院分区：
文献类型：
--
作者：
Butler, Javed;Kalogeropoulos, Andreas;Harris, Tamara B.
目的：抵抗素与炎症和胰岛素抵抗有关，并对心肌细胞产生直接影响，包括肥厚和收缩改变。我们研究了血清抵抗素浓度与人类心力衰竭（HF）发生风险的关系。方法和结果：我们研究了2902名没有普遍HF的老年人（年龄73.6±2.9岁，48.1%男性，58.8%白人），他们参加了健康、衰老和身体成分（Health ABC）研究。基线血清抵抗素浓度（20.3 +/- 10.0 ng/mL）与临床变量、生化指标、炎症和胰岛素抵抗标志物、脂肪细胞因子和肥胖指标之间的相关性较弱（均为rho）
Objective-Resistin is associated with inflammation and insulin resistance and exerts direct effects on myocardial cells including hypertrophy and altered contraction. We investigated the association of serum resistin concentrations with risk for incident heart failure (HF) in humans.Methods and Results-We studied 2902 older persons without prevalent HF (age, 73.6 +/- 2.9 years; 48.1% men; 58.8% white) enrolled in the Health, Aging, and Body Composition (Health ABC) Study. Correlation between baseline serum resistin concentrations (20.3 +/- 10.0 ng/mL) and clinical variables, biochemistry panel, markers of inflammation and insulin resistance, adipocytokines, and measures of adiposity was weak (all rho