HMDB: the Human Metabolome Database.
HMDB: the Human Metabolome Database.
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HMDB：人类代谢组数据库。
DOI：
10.1093/nar/gkl923
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发表时间：
2007-01
影响因子：
14.9
通讯作者：
Querengesser, Lori
中科院分区：
文献类型：
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作者：
Wishart, David S;Tzur, Dan;Knox, Craig;Eisner, Roman;Guo, An Chi;Young, Nelson;Cheng, Dean;Jewell, Kevin;Arndt, David;Sawhney, Summit;Fung, Chris;Nikolai, Lisa;Lewis, Mike;Coutouly, Marie-Aude;Forsythe, Ian;Tang, Peter;Shrivastava, Savita;Jeroncic, Kevin;Stothard, Paul;Amegbey, Godwin;Block, David;Hau, David D;Wagner, James;Miniaci, Jessica;Clements, Melisa;Gebremedhin, Mulu;Guo, Natalie;Zhang, Ying;Duggan, Gavin E;Macinnis, Glen D;Weljie, Alim M;Dowlatabadi, Reza;Bamforth, Fiona;Clive, Derrick;Greiner, Russ;Li, Liang;Marrie, Tom;Sykes, Brian D;Vogel, Hans J;Querengesser, Lori
人类代谢组数据库(HMDB)是目前世界上最完整和最全面的人类代谢物和人类新陈代谢数据的精选集合。它包含2180多种内源性代谢物的记录，信息收集自数千本书籍、期刊文章和电子数据库。除了其全面的文献数据外，HMDB还包含大量实验代谢物浓度数据，这些数据是从对尿液、血液和脑脊液样本进行的数百次质谱(MS)和核磁共振(NMR)代谢分析中汇编而成的。这进一步补充了从纯化的参比代谢物上收集的数千个核磁共振和质谱图。HMDB中的每个代谢物条目平均包含90个单独的数据域，包括全面的化合物描述、名称和同义词、结构信息、物理化学数据、参考核磁共振和质谱图、生物流体浓度、疾病关联、途径信息、酶数据、基因序列数据、SNP和突变数据，以及到图像、参考文献和其他公共数据库的广泛链接。还提供了广泛的搜索、关系查询和数据浏览工具。HMDB旨在满足生物化学家、临床化学家、内科医生、医学遗传学家、营养学家和代谢组学社区成员的广泛需求。HMDB可在以下位置获得：
The Human Metabolome Database (HMDB) is currently the most complete and comprehensive curated collection of human metabolite and human metabolism data in the world. It contains records for more than 2180 endogenous metabolites with information gathered from thousands of books, journal articles and electronic databases. In addition to its comprehensive literature-derived data, the HMDB also contains an extensive collection of experimental metabolite concentration data compiled from hundreds of mass spectra (MS) and Nuclear Magnetic resonance (NMR) metabolomic analyses performed on urine, blood and cerebrospinal fluid samples. This is further supplemented with thousands of NMR and MS spectra collected on purified, reference metabolites. Each metabolite entry in the HMDB contains an average of 90 separate data fields including a comprehensive compound description, names and synonyms, structural information, physico-chemical data, reference NMR and MS spectra, biofluid concentrations, disease associations, pathway information, enzyme data, gene sequence data, SNP and mutation data as well as extensive links to images, references and other public databases. Extensive searching, relational querying and data browsing tools are also provided. The HMDB is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, nutritionists and members of the metabolomics community. The HMDB is available at: