Mammalian MAP kinase signalling cascades
Mammalian MAP kinase signalling cascades
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DOI：
10.1038/35065000
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发表时间：
2001-03-01
期刊：
影响因子：
64.8
通讯作者：
Karin, M
中科院分区：
文献类型：
--
作者：
Chang, LF;Karin, M
丝裂原活化蛋白激酶（Mitogen-activated protein kinases，MAPKs）是真核生物特有的重要信号转导酶，参与细胞调控的多个方面。最初的研究集中在定义MAPK信号级联的组成和组织，但最近的研究已经开始阐明这些级联在控制基因表达，细胞增殖和程序性细胞死亡中的生理功能。
Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes, unique to eukaryotes, that are involved in many facets of cellular regulation. Initial research concentrated on defining the components and organization of MAPK signalling cascades, but recent studies have begun to shed light on the physiological functions of these cascades in the control of gene expression, cell proliferation and programmed cell death.