Gender difference in the non-specific and specific immune response in humans
Gender difference in the non-specific and specific immune response in humans
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DOI：
10.1111/j.1600-0897.2004.00177.x
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发表时间：
2004-07-01
影响因子：
3.6
通讯作者：
Faas, MM
中科院分区：
文献类型：
--
作者：
Bouman, A;Schipper, M;Faas, MM
问题：本离体研究的目的是了解基本非特异性和特异性免疫应答的性别差异。研究方法：通过流式细胞术测量全血制剂中刺激的男性和女性淋巴细胞和单核细胞的细胞内1型和2型细胞因子的产生。产生白细胞介素（IL）-12、IL-1 β和肿瘤坏死因子（TNF）-α的单核细胞百分比增加，产生IL-2的淋巴细胞（即1型细胞因子）百分比降低，结论：这些结果表明，在特异性和非特异性免疫应答之间的平衡方面存在性别差异，也就是说，更深刻和更高的激发状态，与女性相比，男性的特异性免疫应答和特异性免疫系统的细胞免疫应答的相对抑制。
PROBLEM: The purpose of this present ex vivo study is to get insight in the sex differences of the basic non-specific and specific immune response.METHOD OF STUDY: Intracellular types 1 and 2 cytokine production by stimulated male and female lymphocytes and monocytes in a whole blood preparation was measured by flow cytometry.RESULTS: Increased percentage interleukin (IL)-12, IL-1beta and tumor necrosis factor (TNF)-alpha producing monocytes and decreased percentage IL-2 producing lymphocytes, i.e. type 1 cytokine, were found in men as compared with women.CONCLUSION: These results suggest a gender difference in the balance between the specific and non-specific immune response, i.e. a more profound and higher state of excitation of the non-specific immune response and relative suppression of the cellular immune response of the specific immune system in men as compared with women.