Dosimetric study of boron neutron capture therapy with borocaptate sodium (BSH)/lipiodol emulsion (BSH/lipiodol-BNCT) for treatment of multiple liver tumors
Dosimetric study of boron neutron capture therapy with borocaptate sodium (BSH)/lipiodol emulsion (BSH/lipiodol-BNCT) for treatment of multiple liver tumors
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DOI：
10.1016/j.ijrobp.2003.09.084
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发表时间：
2004-03-01
影响因子：
7
通讯作者：
Ono, K
中科院分区：
文献类型：
--
作者：
Suzuki, M;Sakurai, Y;Ono, K
目的：我们进行了一项计算研究，以探讨硼螯合钠(BSH)/脂醇-硼中子俘获治疗（BSH/脂醇-BNCT）治疗多发性肝肿瘤的可行性，该治疗采用了目前可用的BNCT治疗计划系统——模拟放疗应用环境（SERA）。方法与材料：采用SERA系统对4例多发性肝脏肿瘤患者进行BSH/ lipodol - bnct三种治疗方案，两种或三种超热中子束在一个分数中。本研究假设肿瘤和肝脏中B-10浓度分别为197.3 ppm和15.3 ppm；并且是从动物实验研究中获得的。评估每个方案中肝脏肿瘤的治疗增益因子（定义为肿瘤的最小剂量/肝脏的最大剂量）和整个肝脏热中子通量的不均匀性指数（定义为最大中子通量-最小中子通量/平均中子通量）。结果：与对置两束（前后）和正交两束（前后）相比，在患者的前、后、右三侧入射的三束超热中子束能将热中子通量均匀分布到整个肝脏，对右叶肿瘤提供最大的治疗增益因子，对左叶肿瘤提供近似相等的治疗增益因子。结论：从剂量学角度看，采用三束超热中子的BSH/脂醇- bnct治疗方案最适合多发性肝脏肿瘤的治疗。(C) 2004爱思唯尔公司
Purpose: We performed a computational study to investigate the feasibility of borocaptate sodium (BSH)/ lipiodol-boron neutron capture therapy (BSH/lipiodol-BNCT) for multiple liver tumors using Simulation Environment for Radiotherapy Applications (SERA), a currently available BNCT treatment planning system.Methods and Materials: Three treatment plans for BSH/lipiodol-BNCT using two or three epithermal neutron beams in one fraction were generated for 4 patients with multiple liver tumors using the SERA system. The B-10 concentrations in the tumor and the liver assumed in the study were 197.3 and 15.3 ppm, respectively; and were obtained from experimental studies in animals. The therapeutic gain factors for the liver tumors, defined as the minimum dose to the tumor/maximum dose to the liver, and the inhomogeneity index of the thermal neutron fluence for the whole of the liver, defined as the maximum neutron fluence - minimum neutron fluence/mean neutron fluence, were evaluated in each plan.Results: Three epithermal neutron beams incident on the anterior, posterior, and right side of the patient can deliver the most homogeneous distribution of thermal neutron fluence to the whole of the liver and provide the greatest therapeutic gain factors for tumors in the right lobe and approximately equal therapeutic gain factors for tumors in the left lobe, compared with the two opposed (anterior-posterior) and two orthogonal (anterior-right) beams.Conclusions: From a dosimetric viewpoint, the BSH/lipiodol-BNCT treatment plan using three epithermal neutron beams is the most suitable for the treatment of multiple liver tumors. (C) 2004 Elsevier Inc.