Modulation of output from an isolated gastropod heart: Effects of acetylcholine and FMRFamide
Modulation of output from an isolated gastropod heart: Effects of acetylcholine and FMRFamide
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离体腹足动物心脏输出的调节：乙酰胆碱和 FMRFamide 的作用
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
R. Hill
中科院分区：
文献类型：
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作者：
Peter J. S. Smith;R. Hill
在这项研究中，两个心脏活性药物，乙酰胆碱（ACh）和四肽FMRFamide，灌注通过离体系统的腹足类，Busycon canaliculatum心脏。他们的效果是检查输出的调节方面，然后涉及到每搏输出量的体内调节。ACh通过降低每搏输出量和心率来降低心输出量。舒张末期容积和心脏储备随药物浓度增加而增加。这些效应伴随着肌电图前电位上升时间的减慢和平台期持续时间的增加。低浓度的FMRFamide通过加速心率来增加输出。每搏输出量仅在较高浓度（5×10？7摩尔？（1）负向。舒张末期容积减少。10个之间？9和10？8摩尔？1、FMRFamide增加前电位上升时间和平台期振幅，平台期明显缩短。5×10？7摩尔？1及以上时，高原期延长，心脏储备降至零。这两种药物对主动脉压力脉冲的特性有相反的影响：ACh降低脉冲的幅度，但增加其持续时间。
In this study, two cardioactive drugs, acetylcholine (ACh) and the tetrapeptide FMRFamide, are perfused through the isolated systemic heart of the gastropod, Busycon canaliculatum. Their effect is examined in terms of the regulation of output, and is then related to the in vivo regulation of stroke volume. ACh decreases cardiac output by reducing both stroke volume and heart rate. End-diastolic volume and cardiac reserve increase with drug concentration. These effects are accompanied by a slowing in the rise time of the electromyogram prepotential and an increase in the duration of the plateau phase. Low concentrations of FMRFamide increase output by accelerating the heart rate. Stroke volume is only affected at higher concentrations (5×10?7 moll?1), and then negatively. Enddiastolic volume is reduced. Between 10?9 and 10?8 moll?1, FMRFamide increases the rise time of the prepotential and the amplitude of the plateau; the duration of the plateau is markedly shortened. At 5×10?7 moll?1 and above, the plateau is extended and the cardiac reserve is reduced to zero. The two drugs have opposite effects on the characteristics of the aortic pressure pulse: ACh reduces the amplitude of the pulse, but increases its duration.