Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas.
Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas.
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DOI：
10.1210/endo.137.1.8536638
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发表时间：
1996
期刊：
影响因子：
4.8
通讯作者：
S. Jhiang;J. Sagartz;Q. Tong;J. Parker-Thornburg;C. Capen;Je-Yoel Cho;Shunhua Xing;C. Ledent
中科院分区：
文献类型：
--
作者：
S. Jhiang;J. Sagartz;Q. Tong;J. Parker-Thornburg;C. Capen;Je-Yoel Cho;Shunhua Xing;C. Ledent
ret/PTC癌基因是ret原癌基因的重排形式，已发现仅限于人类甲状腺乳头状癌。本报告显示，甲状腺靶向表达ret/PTC 1癌基因的转基因小鼠发生的甲状腺癌与人甲状腺乳头状癌有相当大的相似性，特别是在核细胞学特征和局部浸润的存在下。我们的研究结果表明，ret/PTC 2不仅是与甲状腺乳头状癌相关的生物标志物，而且是唯一被证实的导致甲状腺乳头状癌发展的特异性遗传事件。
The ret/PTC oncogene, a rearranged form of the ret proto-oncogene, has been found to be restricted to human papillary thyroid carcinomas. This report shows that transgenic mice with thyroid-targeted expression of the ret/PTC1 oncogene developed thyroid carcinomas with considerable similarities to human papillary thyroid carcinomas, particularly in the nuclear cytologic features and the presence of local invasion. Our findings indicate that ret/PTC2 is not only a biomarker associated with papillary thyroid carcinomas, but is also the only proven specific genetic event leading to the development of papillary thyroid carcinoma.