Changes in hemodynamics and bradykinin concentration in coronary sinus blood in experimental coronary artery occlusion.
Changes in hemodynamics and bradykinin concentration in coronary sinus blood in experimental coronary artery occlusion.
复制标题
实验性冠状动脉闭塞中冠状窦血液中血流动力学和缓激肽浓度的变化。
DOI：
10.1536/ihj.18.679
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
E. Kimura
中科院分区：
文献类型：
--
作者：
K. Hashimoto;M. Hirose;S. Furukawa;H. Hayakawa;E. Kimura
在17只狗的左冠状动脉前降支急性闭塞前后，对以下参数进行了研究：冠状窦血液中的缓激肽（BK）、心率（HR）、左心室收缩压（LVSP）、左心室舒张末期压（LVEDP）、左心室最大dp/dt（LV max dp/dt）以及心肌收缩力指数（LV max dp/dt/IP）。BK水平升高，在冠状动脉结扎后2分钟达到最大值30 ± 13纳克/毫升，同时伴有LVEDP显著升高和心肌收缩力指数降低。HR和LV max dp/dt无显著变化。BK水平与LVEDP呈正相关，BK水平与LVSP以及心肌收缩力指数呈负相关。用抑肽酶（特血乐）——一种激肽形成酶抑制剂进行预处理，可防止冠状动脉结扎后BK和LVEDP的升高，并使心肌收缩力指数升高。这些结果表明，在缺血心肌内形成的BK对心脏具有负性肌力作用。
The following parameters were studied before and after acute occlusion of the anterior descending branch of the left coronary artery in 17 dogs: bradykinin (BK) in the coronary sinus blood, heart rate (HR), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), left ventricular max dp/dt (LV max dp/dt), and an index of myocardial contractility (LV max dp/dt/IP). BK levels increased, reaching a maximum of 30 +/- 13 ng/ml 2 min after coronary ligation, accompanied by a significant elevation of LVEDP, and lowering of the myocardial contractility index. HR and LV max dp/dt showed no significant changes. A positive correlation obtained between the level of BK and LVEDP, as well as a negative correlation between the level of BK and of both LVSP and myocardial contractility index. Pretreatment with aprotinine (Trasylol), an inhibitor of kinin forming enzyme, prevented the increase in both BK and LVEDP after coronary artery ligation and caused an elevation of myocardial contractility index. These results suggest that BK formed within ischemic myocardium exerts a negative inotropic action on the heart.