Icariin Inhibits Hydrogen Peroxide-Mediated Cytotoxicity by Up-regulating Sirtuin Type 1-Dependent Catalase and Peroxiredoxin
Icariin Inhibits Hydrogen Peroxide-Mediated Cytotoxicity by Up-regulating Sirtuin Type 1-Dependent Catalase and Peroxiredoxin
复制标题
淫羊藿苷通过上调 Sirtuin 1 型依赖性过氧化氢酶和过氧化物酶来抑制过氧化氢介导的细胞毒性
DOI：
10.1111/j.1742-7843.2010.00595.x
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发表时间：
2010-11-01
影响因子：
3.1
通讯作者：
Xu, Yun
中科院分区：
文献类型：
--
作者：
Zhang, Ling;Huang, Siyuan;Xu, Yun
先前的研究表明，黄酮醇淫羊藿苷通过增加SIRT 1来保护缺氧缺糖后的神经元损伤。本研究表明淫羊藿苷能抑制H2 O2诱导的神经毒性。淫羊藿苷的神经保护作用通过对过度产生的自由基的直接清除作用和对细胞抗氧化酶（包括过氧化氢酶（CAT）和过氧化物氧还蛋白1（Prx 1））的表达和活性的间接刺激作用来增强抗氧化能力。该机制可能部分参与了SIRT 1的上调。SIRT 1拮抗剂可部分阻断淫羊藿苷的这种神经保护作用和对CAT/Prx 1的增强作用。这些结果表明淫羊藿苷对H2 O2诱导的神经毒性的作用依赖于增加SIRT 1，并为中风预防和/或治疗提供了一种潜在的新的药理学策略。
Previous studies suggest that flavonol icariin protects against neuron injury after oxygen and glucose deprivation by increasing SIRT1. This study demonstrates that icariin can inhibit H2O2-induced neurotoxicity. The neuroprotection of icariin enhances the antioxidant capacity through both a direct scavenging effect on over-produced free radicals and an indirect stimulating effect on the expression and activity of cellular antioxidant enzymes including catalase (CAT) and peroxiredoxin 1 (Prx1). The mechanism may be partially involved in the up-regulation of SIRT1. The SIRT1 antagonist can partly block this neuroprotection and the enhancement of CAT/Prx1 by icariin. These results indicate that the effect of icariin on H2O2-induced neurotoxicity is dependent on increasing SIRT1 and provides a potentially novel pharmacological strategy for stroke prevention and/or treatment.