Predictability of ventilatory muscle optimal length based on excised dimensions.
Predictability of ventilatory muscle optimal length based on excised dimensions.
复制标题
基于切除尺寸的通气肌最佳长度的可预测性。
DOI：
10.1152/jappl.1992.72.5.2024
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Farkas,GA
中科院分区：
文献类型：
--
作者：
Tao,HY;Farkas,GA
本研究的目的是评估各种呼吸肌的切除长度（切除肌肉的无应力长度; Lex）和最佳力产生长度（Lo）之间的关系，目的是建立一种可靠的方法，使Lo可以快速，容易地估计具有高水平的准确性。实验用18只杂种犬的111条肌束进行。研究了肋膈、胸骨旁肋间肌、斜角肌、胸锁乳突肌、胸骨三角肌、腹直肌、腹外斜肌和腹横肌的节段。我们注意到在离体束中两个固定点之间测量的距离（Lex）和肌肉Lo之间存在线性关系。腹横肌与胸三角肌和腹外斜肌的相关系数为0.83（P <0.01）至0.92（P <0.01）。所有肌肉的合并Lex平均值为61.4 +/- 6.3%（SD）Lo，具体值范围从胸骨三角肌束的55.5 +/- 3.9% Lo到外斜肌束的63.0 +/- 5.1% Lo。在另外三只狗中，我们验证了这种关系的有用性，并从10根肋膈束和10根腹横肌束的切除长度中前瞻性地估计Lo，然后直接测量Lo。膈肌的预测Lo平均值为100.0 +/- 6.0% Lo，腹横肌的预测Lo平均值为97.6 +/- 5.9% Lo。我们的结论是，可以方便和准确地估计从切除的尺寸。这种快速的估计技术应该被证明是有价值的呼吸肌生理学的未来研究。
The purpose of the present study was to assess the relationship between excised length (unstressed length of excised muscle; Lex) and optimal force-generating length (Lo) in a variety of respiratory muscles, with the goal of establishing a reliable method whereby Lo could be rapidly and easily estimated with a high level of accuracy. Experiments were conducted on 111 muscle bundles obtained from 18 mongrel dogs. Segments of costal diaphragm, parasternal intercostal, scalene, sternomastoid, triangularis sterni, rectus abdominis, external oblique, and transversus abdominis muscles were studied. We noted a linear relationship between the distance measured between two fixed points in excised bundles (Lex) and at the muscles' Lo. Correlation coefficients ranged from 0.83 (P less than 0.01) for the transversus abdominis to 0.92 (P less than 0.01) for the triangularis sterni and external oblique muscles. Pooled Lex for all muscles averaged 61.4 +/- 6.3% (SD) Lo, with specific values ranging from 55.5 +/- 3.9% Lo for triangularis sterni bundles to 63.0 +/- 5.1% Lo for external oblique bundles. In three additional dogs, we verified the usefulness of this relationship and prospectively estimated Lo from excised length in 10 costal diaphragm bundles and 10 transversus abdominis bundles and then measured Lo directly. Predicted Lo averaged 100.0 +/- 6.0% Lo for diaphragm and 97.6 +/- 5.9% Lo for transversus abdominis muscle. We conclude that Lo can be conveniently and accurately estimated from excised dimensions. This rapid estimation technique should prove valuable for future studies in respiratory muscle physiology.