New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics.
New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics.
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DOI：
10.1186/s13008-016-0013-6
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发表时间：
2016
期刊：
影响因子：
2.3
通讯作者：
Wan Y
中科院分区：
文献类型：
--
作者：
He M;Zhou Z;Shah AA;Hong Y;Chen Q;Wan Y
翻译后修饰（PTM），例如遍在化、类苏糖基化、乙酰化和蛋白质甲基化，是决定信号蛋白激活、失活或亚细胞定位的关键修饰剂，促进信号传导的启动、放大和转导。越来越多的证据表明，Hippo信号通路中的几个关键信号分子受到不同类型的PTM的严格调控。这些关键信号传导模块如雅普/TAZ、MAT 1/2和LATS 1/2由于失调的PTM而发生的功能障碍与多种人类疾病如癌症有关。本文综述了PTMs在Hippo信号通路中的作用，并从PTMs和Hippo信号通路的角度探讨了潜在的治疗干预。
PTMs (posttranslational modifications) such as ubiquitylation, sumoylation, acetylation and protein methylation are pivotal modifiers that determine the activation, deactivation or subcellular localization of signaling proteins, facilitating the initiation, amplification and transduction of signaling. Accumulating evidence suggest that several key signaling molecules in Hippo signaling pathway are tightly regulated by various types of PTMs. Malfunction of these critical signaling modules such as YAP/TAZ, MAT1/2 and LATS1/2 due to deregulated PTMs has been linked to a variety of human diseases such as cancer. In this review article, we summarized the current understanding of the impact of PTMs in regulating Hippo signaling pathway and further discussed the potential therapeutic intervention from the view of PTMs and Hippo pathway.