The spleen: "epicenter" in malaria infection and immunity.
The spleen: "epicenter" in malaria infection and immunity.
复制标题
DOI：
10.1002/jlb.4ri1020-713r
复制
发表时间：
2021-10
影响因子：
5.5
通讯作者：
Stumhofer JS
中科院分区：
文献类型：
--
作者：
Ghosh D;Stumhofer JS
脾脏是一个复杂的次级淋巴器官，在控制疟原虫寄生虫的血液阶段感染中发挥着至关重要的作用。它的任务是感知和清除寄生的红细胞、红细胞生成、适应性免疫细胞的激活和分化以及保护性免疫的发展，所有这些都是在强烈的炎症环境下进行的。本文描述了感染后如何调节这些过程，并认识到我们当前知识的差距，强调了人类感染和小鼠模型的最新见解。检查疟疾感染期间脾脏的功能；显示该器官如何作为激活和发挥免疫反应中效应机制的中枢，以控制疟原虫寄生虫的血液阶段感染。
The spleen is a complex secondary lymphoid organ that plays a crucial role in controlling blood‐stage infection with Plasmodium parasites. It is tasked with sensing and removing parasitized RBCs, erythropoiesis, the activation and differentiation of adaptive immune cells, and the development of protective immunity, all in the face of an intense inflammatory environment. This paper describes how these processes are regulated following infection and recognizes the gaps in our current knowledge, highlighting recent insights from human infections and mouse models. Reviews the spleen's function during malaria infection; shows how this organ serves as a central hub for activating and exerting effector mechanisms within the immune response to control blood‐stage infection with Plasmodium parasites.
DOI：
10.4049/jimmunol.1601972
发表时间：
2017-09-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Ghosh D;Brown SL;Stumhofer JS
通讯作者：
Stumhofer JS