Gamma/delta T lymphocytes in viral infections.
Gamma/delta T lymphocytes in viral infections.
复制标题
病毒感染中的 Gamma/Delta T 淋巴细胞。
DOI：
10.1002/jlb.58.3.277
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发表时间：
1995
影响因子：
5.5
通讯作者：
Carding,SR
中科院分区：
文献类型：
--
作者：
Wallace,M;Malkovsky,M;Carding,SR
T淋巴细胞祖细胞分化为两种不同的T细胞系。αβ和γδ T细胞系虽然在表型和功能上具有相似性，但也存在显著差异。与αβ T细胞类似，一些γδ T细胞识别主要组织相容性复合体（MHC）蛋白或MHC样分子呈递的肽。然而，与αβ T细胞相比，γδ T细胞以完全不同的方式识别MHC分子。与α β T淋巴细胞相反，许多γδ T细胞能够识别非肽抗原。γδ T细胞的大多数应答似乎是针对微生物病原体，包括细菌、寄生虫和病毒。特别是，γδ T细胞对感染疱疹病毒或慢病毒的细胞的强效细胞毒性反应可能对脊椎动物的整体抗病毒防御至关重要。分析γδ T细胞的抗病毒免疫监视对了解这一淋巴细胞亚群的独特生物学作用至关重要。
T lymphocyte progenitors differentiate into two distinct T cell lineages. Although the αβ and γδ T cell lineages resemble each other phenotypically and functionally, there are some striking differences. Some γδ T cells recognize, similarly to αβ T cells, peptides presented by major histocompatibility complex (MHC) proteins or MHC‐like molecules. However, there are γδ T cells that recognize MHC molecules in a fundamentally different manner in comparison with αβ T cells. Also in contrast to aLβ T lymphocytes, many γδ T cells are capable of recognizing nonpeptide antigens. Most responses of γδ T cells appear to be directed against microbial pathogenic agents including bacteria, parasites, and viruses. In particular, the potent cytotoxic responses of γδ T cells against cells infected with, for example, herpesviruses or lentiviruses may be essential for the overall antiviral defense of vertebrates. The analysis of antiviral immunosurveillance by γδ T cells is crucial for understanding the unique biological role of this lymphocyte subset.