PDGF and Vessel Maturation
PDGF and Vessel Maturation
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DOI：
10.1007/978-3-540-78281-0_7
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Heldin, C. -H.
中科院分区：
文献类型：
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作者：
Hellberg, Carina;Ostman, Arne;Heldin, C. -H.
周细胞是与毛细血管内皮密切接触的平滑肌样细胞，调节血管的形态和功能。在血管形成过程中，周细胞的募集和分化需要血小板衍生生长因子-BB (PDGF-BB)。肿瘤血管表现出异常的形态和增加的内皮增殖，导致血管渗漏、曲折且灌注不良。这些血管通常表现出周细胞密度降低，并且肿瘤相关周细胞通常表达异常标记物并表现出异常形态。针对促血管生成生长因子途径的抗血管生成治疗已应用于广泛的实体瘤，并取得了不同的结果。利用小鼠模型的研究表明，周细胞的存在可以保护内皮细胞免受血管内皮生长因子 (VEGF) 信号传导的抑制。因此，同时抑制周细胞上的 PDGF 受体可改善 VEGF 抑制剂对内皮细胞的作用并增强抗血管生成治疗。
Pericytes are smooth muscle-like cells found in close contact with the endothelium in capillaries, where they regulate the morphology and function of the vessels. During vessel formation, platelet-derived growth factor-BB (PDGF-BB) is required for the recruitment and differentiation of pericytes. Tumor vessels display abnormal morphology and increased endothelial proliferation, resulting in leaky, tortuous vessels that are often poorly perfused. These vessels typically display decreased pericyte density, and the tumor-associated pericytes often express abnormal markers and show abnormal morphology. Anti-angiogenic therapy targeting pro-angiogenic growth factor pathways has been applied to a broad range of solid tumors with varying results. Studies utilizing mouse models indicate that the presence of pericytes protect endothelial cells against inhibition of vascular endothelial growth factor (VEGF) signaling. Simultaneous inhibition of PDGF receptors on pericytes therefore improves the effect of VEGF inhibitors on endothelial cells and enhances anti-angiogenic therapy.