Risk of cataract after exposure to low doses of ionizing radiation: A 20-year prospective cohort study among US radiologic technologists
Risk of cataract after exposure to low doses of ionizing radiation: A 20-year prospective cohort study among US radiologic technologists
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DOI：
10.1093/aje/kwn171
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发表时间：
2008-09-15
影响因子：
5
通讯作者：
Sigurdson, Alice J.
中科院分区：
文献类型：
--
作者：
Chodick, Gabriel;Bekiroglu, Nural;Sigurdson, Alice J.
本研究的目的是确定放射技术人员与职业和非职业电离辐射暴露和个人特征有关的白内障风险。采用两份随访问卷，对35,705名年龄在24-44岁之间的无白内障的美国放射技师进行了近20年（1983-2004年）的前瞻性队列研究。在研究期间，报告了2，382例白内障和647例白内障摘除术。吸烟≥ 5包-年;体重指数≥ 25 kg/m2;基线时有糖尿病、高血压、高胆固醇血症或关节炎病史（p = 3）。对于眼睛透镜职业剂量最高类别（平均60 mGy）与最低类别（平均5 mGy）的工人，白内障的校正危险比为1.18（95%置信区间：0.99，1.40）。研究结果挑战了国家辐射防护理事会和国际辐射防护委员会的假设，即眼睛透镜的最低累积电离辐射剂量可产生进行性白内障约为2戈伊，他们支持的假设，即人类的最低白内障剂量大大低于以前的想法。
The study aim was to determine the risk of cataract among radiologic technologists with respect to occupational and nonoccupational exposures to ionizing radiation and to personal characteristics. A prospective cohort of 35,705 cataract-free US radiologic technologists aged 24-44 years was followed for nearly 20 years (1983-2004) by using two follow-up questionnaires. During the study period, 2,382 cataracts and 647 cataract extractions were reported. Cigarette smoking for >= 5 pack-years; body mass index of >= 25 kg/m(2); and history of diabetes, hypertension, hypercholesterolemia, or arthritis at baseline were significantly (p = 3 x-rays to the face/neck was associated with a hazard ratio of cataract of 1.25 (95% confidence interval: 1.06, 1.47). For workers in the highest category (mean, 60 mGy) versus lowest category (mean, 5 mGy) of occupational dose to the lens of the eye, the adjusted hazard ratio of cataract was 1.18 (95% confidence interval: 0.99, 1.40). Findings challenge the National Council on Radiation Protection and International Commission on Radiological Protection assumptions that the lowest cumulative ionizing radiation dose to the lens of the eye that can produce a progressive cataract is approximately 2 Gy, and they support the hypothesis that the lowest cataractogenic dose in humans is substantially less than previously thought.