Copper(II)-Catalyzed Silyl Conjugate Addition to α,β-Unsaturated Conjugated Compounds: Bronsted Base-Assisted Activation of Si-B Bond in Water
Copper(II)-Catalyzed Silyl Conjugate Addition to α,β-Unsaturated Conjugated Compounds: Bronsted Base-Assisted Activation of Si-B Bond in Water
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DOI：
10.1021/ol300618j
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发表时间：
2012-04-20
期刊：
影响因子：
5.2
通讯作者：
Santos, Webster L.
中科院分区：
文献类型：
--
作者：
Calderone, Joseph A.;Santos, Webster L.
报道了一种温和的将二甲基苯基硅基安装在缺电子烯烃的β-碳上的方法。在催化剂铜(II)(1%)和胺碱(5%)的存在下，转化反应在水中1.5-5 h内有效进行，得到了产率高达90%的β-硅烷化产物。
A mild method for the installation of the dimethylphenylsilyl group on the beta-carbon of electron-deficient olefins is reported. In the presence of a catalytic amount of copper(II) (1 mol %) and amine base (5 mol %) at rt, the transformation proceeds efficiently in water within 1.5-5 h to afford beta-silylated products in yields of up to 90%.